Modeling and optimization studies for a sequential flow based bio-analytical system

Sequential injection analysis

“…After in-line sample preconcentration, 240 multilinear regression applied to first-derivative absorbance spectra (photodiode array, 280-600 nm) allowed the simultaneous determination of three nitrophenols in water, with results which correlated well with those obtained using GC methodology. An axial dispersed plug mathematical model incorporating temperature dependence factors for viscosity, diffusion coefficients and reaction kinetics was developed by Parab et al 241 for the optimisation of a critical care blood glucose analyser.…”

New horizons in sequential injection kinetic analysis

“…After a certain time a known volume of the solution product was withdrawn from the mixing chamber and transferred into the holding coil before being channelled to the spectrophotometric detector for measurement. A mathematical model [96] was developed to describe the behaviour of a flow-based bio-analytical Raichem glucose analyser. The analyser was operated in the sequential injection mode and was equipped with a phosphate buffer, 4-aminoantipyridine, the sodium salt of p-hydroxybenzene sulfonate, and glucose oxidase.…”