With the continuous improvement of people’s living standards, especially under the influence of shopping festivals such as “618”, “Double 11,” and “Double 12”, the competition in the express delivery industry is becoming increasingly fierce. Since there is no express cabinet in many areas, it is necessary to go to the express station to pick up the parcel in person. Therefore, pick-up efficiency affects the customer’s satisfaction with the express station. To improve customer satisfaction, we must first improve the efficiency of pick-up. Many express companies now adopt a combination of self-service and manual methods to solve the problem of too long waiting times in picking up parcels. However, it is still inevitable that there will be too long waiting times in shopping festivals due to the explosion of express delivery. In order to improve the pick-up efficiency, this paper uses Arena to establish a simulation model to simulate the pick-up waiting situation and allocate the number of self-service pick-up machines and manual services to solve the problem of excessively long waiting times during pick-up.