Modeling and simulation of bone cells dynamic behavior under the late effect of breast cancer treatments

Oumghar, Imane Ait; Barkaoui, Abdelwahed; Ghazi, Abdellatif El; Chabrand, Patrick

doi:10.1016/j.medengphy.2023.103982

Medical Engineering & Physics

2023

DOI: 10.1016/j.medengphy.2023.103982

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Modeling and simulation of bone cells dynamic behavior under the late effect of breast cancer treatments

Imane Ait Oumghar

Abdelwahed Barkaoui

Abdellatif El Ghazi

et al.

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2023

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“…Building on our previous works 4,11 which were principally dedicated to mathematical modeling of bone remodeling under BC and BC treatments effect, this paper delves deeper into the mechanical behavior of bone under breast cancer and its treatment effects at the macroscopic level. Our previous study utilized mathematical modeling to understand the underlying mechanisms of breast cancer/ treatments-bone remodeling cells interactions.…”

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confidence: 99%

Chemotherapy and adjuvant therapies' impact on the internal remodeling process of bone and its mechanical behavior for breast cancer patients

Ait Oumghar,

Barkaoui,

Merzouki

et al. 2023

Numer Methods Biomed Eng

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Breast cancer is a significant public health issue affecting women worldwide. While advancements in treatment options have led to improved survival rates, the impact of breast cancer and its treatments on bone health cannot be overlooked. Bone remodeling is a complex process regulated by the delicate balance between bone formation and resorption. Any disruption to this balance can lead to decreased bone density, increased fracture risk, and compromised physical function. To investigate the effects of breast cancer and its treatments on bone remodeling, a finite element model was developed in this study. This model incorporated bone remodeling equations to simulate the mechanical behavior of bone under different conditions. The ABAQUS/UMAT software was used to simulate the behavior of bone tissue under the influence of breast cancer and treatments. Our findings suggest that bone loss is more pronounced after secondary breast cancer and treatment, leading to bone loss (6%–19% decrease in BV/TV), reduced bone stimulation, and decreased effectiveness of physical activity on recovery. These results highlight the importance of early intervention and management of bone health in breast cancer patients to mitigate the negative impact of cancer and treatment on bone remodeling.

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confidence: 99%

Chemotherapy and adjuvant therapies' impact on the internal remodeling process of bone and its mechanical behavior for breast cancer patients

Ait Oumghar,

Barkaoui,

Merzouki

et al. 2023

Numer Methods Biomed Eng

Self Cite

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Modeling and simulation of bone cells dynamic behavior under the late effect of breast cancer treatments

Cited by 1 publication

References 45 publications

Chemotherapy and adjuvant therapies' impact on the internal remodeling process of bone and its mechanical behavior for breast cancer patients

Chemotherapy and adjuvant therapies' impact on the internal remodeling process of bone and its mechanical behavior for breast cancer patients

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