Modeling and simulation of opto-fluidic based Mach-Zehnder interferometer for biosensing application

Shwetha, M.; Kumar, Manoranjan; Narayan, K. S.

doi:10.1109/wrap.2015.7806021

Cited by 5 publications

(3 citation statements)

References 7 publications

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“…An evanescent field results from some of the light radiating into the cladding after it passes through the waveguide's core. The optical characteristics of this evanescent field are influenced by the concentration of the bio sample resulting in measurement of glucose concentration 1,5 . In this proposed work measured concentration of glucose in sample based on RI change of biosensor.…”

Section: Introductionmentioning

confidence: 99%

Four layer integrated optical biosensor

Manchikalapati,

VL,

Talabattula

2024

SPIE Advanced Biophotonics Conference (SPIE ABC 2023)

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Integrated optical biosensors are capable of combining properties of miniaturization, stability and high sensitivity. In this paper a novel integrated optic biosensor for the measurement of glucose concentration in the blood design is proposed and analysed mathematically. The configuration is based on silicon on insulator technology and consists of four layers, the oxide substrate layer, thin silicon nitride layer to enhance the sensitivity, the silicon ridge waveguide optical guiding layer, and the cover layer consisting of bio-analyte to be measured. The main idea in this configuration is the introduction of thin nitride layer in between silicon and silicon dioxide. Then it was observed that in the case of three layer waveguide the mode penetration into the cladding influences the sensitivity. Introduction of silicon nitride layer between the oxide and guiding layer reduces the refractive index contrast between the substrate and the guiding layer resulting in increased penetration depth we obtain a sensitivity of 1%, in terms of effective refractive index change.

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Section: Introductionmentioning

confidence: 99%

Four layer integrated optical biosensor

Manchikalapati,

VL,

Talabattula

2024

SPIE Advanced Biophotonics Conference (SPIE ABC 2023)

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“…LCW devices have shown great advantages in the meantime. − Pan et al employed a two-LED LCW absorbance detector for DNA sample measurement operating at 260 and 280 nm with a photodiode detector. DNA sample concentration was measured with a 15 mm effective light path and 350 nL sample consumption .…”

mentioning

confidence: 99%

“…16 LCW devices have shown great advantages in the meantime. 17 19 Some other studies also put focus on longer optical path for a higher sensitivity; for example, Bai et al reported a 70 mm metal-waveguide-capillary (MWC) path length photometer with a glucose detection limit of 5.12 nM. 21 However, these devices suffered from the risk of cross contamination and barely change the workflow.…”

mentioning

confidence: 99%

Hand-Held Photometer for Instant On-Spot Quantification of Nucleic Acids, Proteins, and Cells

Jain²,

Tscharntke³

et al. 2018

Anal. Chem.

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This paper presents a novel hand-held photometer, termed "Photopette", for on-spot absorbance measurements of biochemical analytes. The Photopette is a multicomponent, highly portable device with an overall weight of 160 g, which fits within 202 mm × 47 mm × 42 mm. Designed in the form factor of a micropipette, Photopette integrates a photodiode detector with light emitting diodes (LEDs) to form a highly customizable photometer which supports a wide variety of applications within the wavelengths between 260 and 1050 nm. A dual-purpose disposable reflective tip was designed to act as a sample holder and a light-reflecting system, which is in stark contrast to the operation of mainstream spectrophotometers and photometers. Small volume analytes may be measured with low sample loss using this proprietary CuveTip. A user-friendly software application running on smart devices was developed to control and read the values from Photopette via a low-energy Bluetooth link. This one-step strategy allows measurements on-spot without sample transfer, minimizing cross-contamination and human error. The results reported in this paper demonstrate Photopette's great potential to quantify DNA, direct protein, and cell density directly within the laminar flow hood. Results are compared with a Nanodrop 2000c spectrophotometer, a mainstream spectrophotometer for small-volume measurements.

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