Modeling and simulation of Positron Emission Mammography (PEM) based on double-sided CdTe strip detectors

Ozsahin, Ilker; Unlu, Mehmet Z.

doi:10.1088/1748-0221/9/03/c03055

Cited by 4 publications

(4 citation statements)

References 21 publications

(32 reference statements)

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“…Nevertheless, the low collection efficiency of the holes in CdTe results in a low energy resolution compared to Germanium or Silicon [4]. For medical imaging devices, this detector material is the most feasible as it is very good in applications connected to nuclear medicine [5][6][7][8]. Presently, majority of the nuclear medicine imaging devices employing CdTe as the detector material are organ-dedicated systems for cardiac, breast, and brain imaging, and also some systems for preclinical studies due to its high cost.…”

Section: Commonly Used Solid-state Crystalsmentioning

confidence: 99%

“…It has a high-sensitivity and a good energy resolution similar to that of CdTe [9]. There has been an extensive research on this compound semiconductor in medical imaging, astronomy, and general gamma-ray spectroscopy fields [5][6][7][8]10]. It offers several advantages such as direct conversion of radiation into electronhole pairs, good spatial and energy resolution, and room temperature operation.…”

Section: Commonly Used Solid-state Crystalsmentioning

confidence: 99%

See 1 more Smart Citation

Evaluation of solid-state detectors in medical imaging with fuzzy PROMETHEE

Ozsahin¹,

Sharif

Ozsahin³

et al. 2019

J. Inst.

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Section: Commonly Used Solid-state Crystalsmentioning

confidence: 99%

Section: Commonly Used Solid-state Crystalsmentioning

confidence: 99%

Evaluation of solid-state detectors in medical imaging with fuzzy PROMETHEE

Ozsahin¹,

Sharif

Ozsahin³

et al. 2019

J. Inst.

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“…Since that period, there has been a trend of developing newer modalities such as molecular breast imaging, breast specific gamma imaging and positron emission mammography [1]. Fundamental issues related to the image acquisition modes, sensitivity, spatial resolution and radiation dose were addressed, including the radiopharmaceuticals used to diagnose the disease [1][2][3].…”

Section: Introductionmentioning

confidence: 99%

Simulation and evaluation of high-performance cost-effective positron emission mammography scanner

Musa¹,

Ozsahin²,

Ozsahin³

2018

J. Inst.

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Breast cancer is the main cause of tumor deaths in women, thus several imaging modalities have been introduced recently to better diagnose the disease. New breast cancer cases were estimated to reach up to 246,660 in 2017, and the mortality rate was above 40,000. Early diagnosis is widely approved as being essential for an effective treatment and it also helps to reduce the incidences and mortality rates. Positron Emission Mammography (PEM) is a breast-dedicated imaging device which uses a pair of annihilation gamma photons to detect abnormalities in the breast tissue. PEM device is compact in nature with a reduced field of view to cover the entire breast region, and it employs few detector modules which makes it cost-efficient. To effectively diagnose breast cancer at a very early stage, a device with high spatial resolution and high sensitivity is required. PEM detectors based on semiconductor materials are characterized by an excellent intrinsic spatial resolution but are not cost-effective, whereas detectors based on scintillator crystals are cost-effective but have limited intrinsic resolution to detect small breast lesions. This study focuses on improving the resolution of scintillator detectors by simulating a PEM scanner employing 1 × 1 × 10 mm3 laser processed scintillator crystal. The simulation was done with a GEANT4 application for emission tomography (GATE) software, and performance evaluation tests were carried out according to the National Electrical Manufacturers Association (NEMA) standards. The scanner geometry has 90 mm transaxial field of view (FOV) and 105 mm axial FOV. Evaluation results showed that the scanner has 10.6% system sensitivity, 1.0 mm spatial resolution at the center of the FOV (CFOV) and at 2.5 cm transaxial direction. The resolution at the axial 2.5 cm position is 2.1 mm. NEMA image quality test and Derenzo phantom study showed that the scanner can easily resolve 1 mm in diameter hot rods.

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“…The last two decades have witnessed a trend in the design of organ dedicated scanners with the aim of addressing the issues of WB scanners. In the new proposed designs, problems such as noncollinearity, sensitivity, resolution and cost were addressed [6][7][8][9][10]. These scanner geometries have a reduced field of view (FOV) to the region of interest, which increases their geometric efficiency.…”

mentioning

confidence: 99%

Simulation of novel scintillator crystals for brain PET

Ozsahin

Ozsahin²,

Makarov³

et al. 2020

J. Inst.

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In the last decade, different positron emission tomography (PET) crystals have been proposed for brain PET detectors. Brain PET cameras with restricted field of view to a smaller size to cover the brain can both exhibit significantly higher performance and lower the cost when compared to conventional whole-body PET scanners. The existing designs based on scintillation crystals employ the most commonly known materials such as lutetium oxyorthosilicate and bismuth germanate. This is due to their relatively good parameters such as high light yield and density. The main drawback of using scintillation crystals is that they have a modest energy resolution. In this study, a brain PET scanner was designed and simulated using a Geant4 Application for Tomographic Emission (GATE) toolkit. The performances of five crystals, namely strontium hafnate, gadolinium aluminium gallium garnet, gadolinium yttrium gallium aluminium garnet, gadolinium lutetium gallium aluminium garnet, and lutetium oxyorthosilicate for comparison, were evaluated in terms of sensitivity, spatial resolution, and count rate. The performance evaluation results showed that among the suggested scintillators, strontium hafnate can be considered as a promising alternative detector for high performance brain PET systems. K: Gamma camera, SPECT, PET PET/CT, coronary CT angiography (CTA); Medicalimage reconstruction methods and algorithms, computer-aided diagnosis; Medical-image reconstruction methods and algorithms, computer-aided software; Scintillators, scintillation and light emission processes (solid, gas and liquid scintillators) 1Corresponding author.

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Modeling and simulation of Positron Emission Mammography (PEM) based on double-sided CdTe strip detectors

Cited by 4 publications

References 21 publications

Evaluation of solid-state detectors in medical imaging with fuzzy PROMETHEE

Evaluation of solid-state detectors in medical imaging with fuzzy PROMETHEE

Simulation and evaluation of high-performance cost-effective positron emission mammography scanner

Simulation of novel scintillator crystals for brain PET

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