Titanium alloy is a type of high-strength material that is difficult to process. In particular, in the aerospace field, the processing accuracy of titanium alloy is high. Recently, laser processing has emerged as a new technology with high processing precision. However, the laser processing methods have obvious differences in processing accuracy and effect. Among them, the laser spiral scanning method plays an important role in welding and drilling, but owing to the complexity of the laser molten pool behavior, there have been limited studies on the material removal mechanism based on laser spiral scanning. To understand the variable process of titanium alloy melt pool in laser spiral scanning processing, a light heat conduction model with mass transfer source term was simulated. The effects of laser power, scanning speed, and scanning path on the morphology were studied. The simulation results show that the unit energy density was the main factor for material removal, and the distribution of the material temperature affected the size of the recast layer. The experimental and simulation results were compared, and good agreement between them was observed. This study can provide a research foundation for the further application of laser spiral scanning technology.