2023
DOI: 10.3389/fimmu.2023.1104605
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Modeling antibody dynamics following herpes zoster indicates that higher varicella-zoster virus viremia generates more VZV-specific antibodies

Abstract: IntroductionStudying antibody dynamics following re-exposure to infection and/or vaccination is crucial for a better understanding of fundamental immunological processes, vaccine development, and health policy research.MethodsWe adopted a nonlinear mixed modeling approach based on ordinary differential equations (ODE) to characterize varicella-zoster virus specific antibody dynamics during and after clinical herpes zoster. Our ODEs models convert underlying immunological processes into mathematical formulation… Show more

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Cited by 2 publications
(1 citation statement)
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“…Furthermore, Keersmaekers et al 19 used the mixed effect modeling to investigate two vaccine doses. Another recent study by Besbassi et al 20 employed mixed-effects ODE models to examine antibody dynamics following re-exposure to infection. The approach was applied to 61 herpes zoster patients to gain insights into varicella-zoster virus specific antibody dynamics during and after clinical herpes zoster.…”
Section: Introductionmentioning
confidence: 99%
“…Furthermore, Keersmaekers et al 19 used the mixed effect modeling to investigate two vaccine doses. Another recent study by Besbassi et al 20 employed mixed-effects ODE models to examine antibody dynamics following re-exposure to infection. The approach was applied to 61 herpes zoster patients to gain insights into varicella-zoster virus specific antibody dynamics during and after clinical herpes zoster.…”
Section: Introductionmentioning
confidence: 99%