Modeling Blood Flow Through Intracranial Aneurysms: A Comparison of Newtonian and Non-Newtonian Viscosity

Carty, Gregory; Chatpun, Surapong; Espino, Daniel M.

doi:10.1007/s40846-016-0142-z

Cited by 38 publications

(40 citation statements)

References 45 publications

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“…The maximum and minimum strain are in the same region of the channel for all models, which makes them consistent results among themselves and close to other authors, namely Bazilevs et al [41] and Carty et al [13] . After strain and displacement analysis across the channel, some points along the aneurysm dome were analyzed, according to the z direction (fluid flow direction) and the x direction, Fig.…”

Section: Resultssupporting

confidence: 91%

“…To analyze the mechanical behavior of blood vessels two approaches are usually used-in vitro exper-imental studies [7][8][9] and numerical simulations [10][11][12][13] . In the former studies, silicone in vitro devices were developed [7][8][9] to mimic the biomechanical behavior of real blood vessels [14] or cadaveric arteries were used to analyze some mechanical properties [15] .…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Biomechanical analysis of PDMS channels using different hyperelastic numerical constitutive models

Cardoso¹,

Fernandes²,

Lima³

et al. 2018

Mechanics Research Communications

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a b s t r a c tBrain aneurysms are pathological dilatations of cerebral arteries and are known as one of the most common and serious cerebrovascular events. However, patients with cerebral aneurysms do not exhibit evident symptoms until they rupture. The main objective of the present study is to perform numerical characterizations of the biomechanical behavior of aneurysms in order to analyze the blood vessel wall behavior during the formation of an aneurysm. By taking into account different geometric and physiological parameters, flow simulations of a well-known Newtonian fluid (glycerin) was performed using the commercial finite volume method package Ansys® -Fluent, and pressure along the channel was determined. These pressures were imported into the channel, in the Ansys®-Static Structural, in order to evaluate and analyze the displacement and strain fields in the channel wall, caused by the internal pressure induced by the fluid flow. All calculations were performed by using the most widely accepted hyperelastic constitutive models and it was found that any constitutive model can be applied to this kind of studies, allowing to visualize where pressure achieves its maximum value and consequently, the most favorable region where the rupture is more likely to occur.

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Section: Resultssupporting

confidence: 91%

Section: Introductionmentioning

confidence: 99%

Biomechanical analysis of PDMS channels using different hyperelastic numerical constitutive models

Cardoso¹,

Fernandes²,

Lima³

et al. 2018

Mechanics Research Communications

View full text Add to dashboard Cite

show abstract

“…However, in regions with slow blood flow or vessels of dimensions smaller than those considered here, non-Newtonian properties will become important [33]. The effect of non-Newtonian properties [43] on the energy loss parameter will be left for further study.…”

Section: Discussionmentioning

confidence: 90%

A Computational Hemodynamics Analysis on the Correlation Between Energy Loss and Clinical Outcomes for Flow Diverters Treatment of Intracranial Aneurysm

et al. 2018

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Rupture of intracranial aneurysms might lead to permanent disability or even death. One possible endovascular treatment is to deploy flow diverters (FDs), reducing flow into the sac and promoting thrombosis. Computational fluid dynamics simulations were used to assess the flow patterns and dynamics. The concept of energy loss, as a measure of work done necessary to overcome flow resistance, will be utilized to correlate with clinical outcome. If a surgical operation is successful, the flow is diverted to a shorter path and energy loss should be reduced. Conversely, persistent flow in the sac associated with treatment failure will display increased energy loss, as blood is then squeezed through the stent pores. Four illustrative clinical cases, involving both bifurcation and sidewall aneurysms, were selected. To reduce the numerical complexity, earlier works in the literature had employed a porous medium approximation for the FDs. Here the FD was simulated explicitly as a virtual (or computer generated) stent which would likely provide a more accurate description. Furthermore, quantitative comparisons between the approaches of virtual stent and porous medium with typical parameters were conducted by examining the effective flow influx into the aneurysm.

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“…The definition of parameters which describe anatomy is somewhat analogous to a recent morphometry based toolbox generated for the spine [ 40 ]; though, in our current study, disease has been defined too. The refinement of an accessible additively manufactured model can be applied to countless different blood vessels with complementarity to: development of stents; diagnosis of stenosis severity and surgical intervention requirements; patient specific blood flow modelling [ 41 , 42 ] or validation of computational models [ 43 , 44 ]; and improvement in the results of clinical treatment through detailed preoperative planning [ 45 ]. As there are biocompatible grades of PDMS [ 46 ], any 3D printed constructs hold potential for translation into clinical practice: patient specific implants [ 47 ], but for soft tissues.…”

Section: Discussionmentioning

confidence: 99%

Towards Additive Manufacture of Functional, Spline-Based Morphometric Models of Healthy and Diseased Coronary Arteries: In Vitro Proof-of-Concept Using a Porcine Template

Jewkes

Burton

Espino

2018

JFB

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The aim of this study is to assess the additive manufacture of morphometric models of healthy and diseased coronary arteries. Using a dissected porcine coronary artery, a model was developed with the use of computer aided engineering, with splines used to design arteries in health and disease. The model was altered to demonstrate four cases of stenosis displaying varying severity, based on published morphometric data available. Both an Objet Eden 250 printer and a Solidscape 3Z Pro printer were used in this analysis. A wax printed model was set into a flexible thermoplastic and was valuable for experimental testing with helical flow patterns observed in healthy models, dominating the distal LAD (left anterior descending) and left circumflex arteries. Recirculation zones were detected in all models, but were visibly larger in the stenosed cases. Resin models provide useful analytical tools for understanding the spatial relationships of blood vessels, and could be applied to preoperative planning techniques, but were not suitable for physical testing. In conclusion, it is feasible to develop blood vessel models enabling experimental work; further, through additive manufacture of bio-compatible materials, there is the possibility of manufacturing customized replacement arteries.

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Modeling Blood Flow Through Intracranial Aneurysms: A Comparison of Newtonian and Non-Newtonian Viscosity

Cited by 38 publications

References 45 publications

Biomechanical analysis of PDMS channels using different hyperelastic numerical constitutive models

Biomechanical analysis of PDMS channels using different hyperelastic numerical constitutive models

A Computational Hemodynamics Analysis on the Correlation Between Energy Loss and Clinical Outcomes for Flow Diverters Treatment of Intracranial Aneurysm

Towards Additive Manufacture of Functional, Spline-Based Morphometric Models of Healthy and Diseased Coronary Arteries: In Vitro Proof-of-Concept Using a Porcine Template

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