2021
DOI: 10.1007/s10409-021-01088-w
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Modeling cells spreading, motility, and receptors dynamics: a general framework

Abstract: The response of cells during spreading and motility is dictated by several multi-physics events, which are triggered by extracellular cues and occur at different time-scales. For this sake, it is not completely appropriate to provide a cell with classical notions of the mechanics of materials, as for “rheology” or “mechanical response”. Rather, a cell is an alive system with constituents that show a reproducible response, as for the contractility for single stress fibers or for the mechanical response of a bio… Show more

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Cited by 15 publications
(17 citation statements)
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“…Cell mechanical response can be assigned either to the bulk of the cell or to the cell membrane. The former choice, supported by [ 29 , 30 , 31 , 32 , 34 , 35 , 36 , 37 , 44 , 45 , 104 ], for instance, implies the assignment of the cell structural response to the cytoskeleton remodeling; alternatively, other authors demand the structural functions to the cell membrane, for instance [ 105 , 106 , 107 , 108 , 109 ]. Despite studies on red blood cells providing a description of the cell membrane deformation at a constant area [ 110 ], the influence of curvature on the membrane elastic stiffness is related to cell dimensions.…”
Section: Discussionmentioning
confidence: 99%
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“…Cell mechanical response can be assigned either to the bulk of the cell or to the cell membrane. The former choice, supported by [ 29 , 30 , 31 , 32 , 34 , 35 , 36 , 37 , 44 , 45 , 104 ], for instance, implies the assignment of the cell structural response to the cytoskeleton remodeling; alternatively, other authors demand the structural functions to the cell membrane, for instance [ 105 , 106 , 107 , 108 , 109 ]. Despite studies on red blood cells providing a description of the cell membrane deformation at a constant area [ 110 ], the influence of curvature on the membrane elastic stiffness is related to cell dimensions.…”
Section: Discussionmentioning
confidence: 99%
“…The authors of this review studied the relocation of transmembrane receptors along advecting cell membranes, like for Vascular Endothelial Growth Factor Receptors 2 (VEGFR2) and integrins, by designing chemo-transport-mechanical multi-physics formulations [ 42 , 43 , 44 , 45 ] to describe how the mechanical behavior of an endothelial cell (EC) affects receptor dynamics during the early phases of tumor angiogenesis. VEGFR2 dynamics on cell membranes was studied in [ 42 ] for EC adhesion onto a rigid substrate coated with specific immobilized ligands, on the basis of the established role as activator of the angiogenic process of the chemical interactions between soluble non-canonical ligands, as gremlins [ 46 , 47 ], released by cancer cells.…”
Section: Continuum Models Of Receptor Motilitymentioning
confidence: 99%
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“…The majority of studies on the accuracy of biological sensors treat each sensor as a single-variable information transducer, which measures only one of the multiple independent traits of a complex environment (e.g., mechanical force, temperature, or concentration) [17][18][19]. As an example, most studies of ligand-receptor sensors have shared an assumption that the receptor is mainly capable of measuring the ligand concentration [20].…”
Section: Introductionmentioning
confidence: 99%
“…Although several studies attempted at capturing the processes that drive cell motility (see [13] and literature therein), a comprehensive model of the cytoskeletal machinery is not yet available in the literature. This note does not attempt at proposing a new theory either.…”
Section: Introductionmentioning
confidence: 99%