“…Cell mechanical response can be assigned either to the bulk of the cell or to the cell membrane. The former choice, supported by [ 29 , 30 , 31 , 32 , 34 , 35 , 36 , 37 , 44 , 45 , 104 ], for instance, implies the assignment of the cell structural response to the cytoskeleton remodeling; alternatively, other authors demand the structural functions to the cell membrane, for instance [ 105 , 106 , 107 , 108 , 109 ]. Despite studies on red blood cells providing a description of the cell membrane deformation at a constant area [ 110 ], the influence of curvature on the membrane elastic stiffness is related to cell dimensions.…”