It should be remarked that the basic knowledge collected from complicated area of the structuration process of the organic materials, including the liquid crystal (LC) ones, useful for the optoelectronics and biomedicine, requires extending the types of the novel matrix model materials and the class of the dopants, which can change the spectral and photorefractive features of the matrixes with good advantage. In the current paper the effect of the introduction of the bio-objects (based on DNA) and of the nano-objects (based on fullerenes, quantum dots, carbon nanotubes, shungites, graphenes) in the organic conjugated materials has been comparatively discussed. The influence of this process on the photorefractive features, namely on the laser-induced change of the refractive index, has been studied. The clear innovative tendency of the alternative using of the bio-objects together or instead of the nano-objects ones has been analyzed via considering of the modification of the spectral and non-linear optical characteristics.