1996
DOI: 10.1128/aac.40.5.1143
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Modeling combinations of antiretroviral agents in vitro with integration of pharmacokinetics: guidance in regimen choice for clinical trial evaluation

Abstract: We propose a method for the selection of doses and dosing schedule for drugs to be used in combination. This approach uses the simulation of steady-state concentrations of the drugs in the combination and overlays these concentrations onto a three-dimensional effect surface. The MacSynergy II program is used to construct the three-dimensional drug interaction surface from the direct evaluation of drug combination effect in vitro. The study examined the combination of an inhibitor of the human immunodeficiency … Show more

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Cited by 8 publications
(5 citation statements)
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“…However, the concentration needed to reach a specific effect can be substantially decreased, as is evident from isobolographic analysis. This should be taken into account especially when interactions are studied in order to guide clinical trials [36].…”
Section: Discussionmentioning
confidence: 99%
“…However, the concentration needed to reach a specific effect can be substantially decreased, as is evident from isobolographic analysis. This should be taken into account especially when interactions are studied in order to guide clinical trials [36].…”
Section: Discussionmentioning
confidence: 99%
“…From these data, the 50% inhibitory concentration (IC 50 ), was calculated using the MacSynergy II Software [28]. Controls for inhibition experiments included vehicle buffer, bovine serum albumin (up to 30 µM) and a heparin control resembling the hep-ATIII purification step.…”
Section: Methodsmentioning
confidence: 99%
“…Different drug concentrations were used in a virus-specific cell-based assay to measure inhibition. From these data, the IC50, was calculated using the MacSynergy II Software [27]. Controls for inhibition experiments included vehicle buffer, bovine serum albumin (up to 30 µM) and a heparin only control.…”
Section: Methodsmentioning
confidence: 99%