Modeling combined transport of water and charged graded-size molecules across the glomerular capillary wall

Mohamed, Ehab I.; Bayoumi, Amani M.

doi:10.1016/j.bbrc.2010.04.042

Cited by 2 publications

(1 citation statement)

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“…According to the modern two-pore theory of transvascular exchange, transcapillary leakage of macromolecules occurs through the large pores of the capillary/venular membrane and also appears to be greater at increased permeability [ 9 ]. In addition to the size and number of the large pores, transcapillary leakage may be influenced by the charge of the molecules and their interaction with the glycocalyx and other endothelial structures [ 10 ]. However, current research indicates that the (extended) use of colloid solutions is associated with increased frequency of renal replacement therapy in critically ill patients [ 11 ].…”

Section: Introductionmentioning

confidence: 99%

6% Hydroxyethyl starch (HES 130/0.4) diminishes glycocalyx degradation and decreases vascular permeability during systemic and pulmonary inflammation in mice

et al. 2018

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BackgroundIncreased vascular permeability is a pathophysiological hallmark of sepsis and results in increased transcapillary leakage of plasma fluid, hypovolemia, and interstitial edema formation. 6% hydroxyethyl starch (HES 130/0.4) is commonly used to treat hypovolemia to maintain adequate organ perfusion and oxygen delivery. The present study was designed to investigate the effects of 6% HES 130/0.4 on glycocalyx integrity and vascular permeability in lipopolysaccharide (LPS)-induced pulmonary inflammation and systemic inflammation in mice.Methods6% HES 130/0.4 or a balanced electrolyte solution (20 ml/kg) was administered intravenously 1 h after cecal ligation and puncture (CLP) or LPS inhalation. Sham-treated animals receiving 6% HES 130/0.4 or the electrolyte solution served as controls. The thickness of the endovascular glycocalyx was visualized by intravital microscopy in lung (LPS inhalation model) or cremaster muscle (CLP model). Syndecan-1, hyaluronic acid, and heparanase levels were measured in blood samples. Vascular permeability in the lungs, liver, kidney, and brain was measured by Evans blue extravasation.ResultsBoth CLP induction and LPS inhalation resulted in increased vascular permeability in the lung, liver, kidney, and brain. 6% HES 130/0.4 infusion led to significantly reduced plasma levels of syndecan-1, heparanase, and hyaluronic acid, which was accompanied by a preservation of the glycocalyx thickness in postcapillary venules of the cremaster (0.78 ± 0.09 μm vs. 1.39 ± 0.10 μm) and lung capillaries (0.81 ± 0.09 μm vs. 1.49 ± 0.12 μm).ConclusionsThese data suggest that 6% HES 130/0.4 exerts protective effects on glycocalyx integrity and attenuates the increase of vascular permeability during systemic inflammation.Electronic supplementary materialThe online version of this article (doi: 10.1186/s13054-017-1846-3) contains supplementary material, which is available to authorized users.

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Section: Introductionmentioning

confidence: 99%