This study assessed the knowledge and perception of Nigerians about COVID-19 vaccination. A cross-sectional survey was conducted comprising Health and Non-health workers in Nigeria. The knowledge, attitude, and perception of respondents on COVID-19 vaccination in Nigeria was obtained through an online. Logistic regression was employed to determine which factor imparted on COVID-19 vaccination decision. The study showed a significant relationship between COVID-19 vaccination and immigration requirements. The survey showed that 74.07% of the health workers had been vaccinated, while 47.06% of non-Health Workers had been vaccinated. This study recommends that Governments at all levels should create more awareness of the importance of COVID-19 vaccination to increase the number of vaccinated individuals.