2023
DOI: 10.1002/btm2.10592
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Modeling diabetic endothelial dysfunction with patient‐specific induced pluripotent stem cells

Rayyan Gorashi,
Nancy Rivera‐Bolanos,
Caitlyn Dang
et al.

Abstract: Diabetes is a known risk factor for various cardiovascular complications, mediated by endothelial dysfunction. Despite the high prevalence of this metabolic disorder, there is a lack of in vitro models that recapitulate the complexity of genetic and environmental factors associated with diabetic endothelial dysfunction. Here, we utilized human induced pluripotent stem cell (iPSC)‐derived endothelial cells (ECs) to develop in vitro models of diabetic endothelial dysfunction. We found that the diabetic phenotype… Show more

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Cited by 7 publications
(1 citation statement)
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“…Induced pluripotent stem cells (iPSCs) may provide better cell models due to their ability to differentiate into a wide range of cell types and unlimited growth in vitro. They have been used to study many inherited conditions in humans (Mae et al, 2023, Fear et al, 2023, Gorashi et al, 2023 and are of particular value when access to the affected cell types is limited and/or the cells do not expand well in culture (Pereira et al, 2023). More recently human iPSCs have been used in conjunction with polygenic risk scores (Dobrindt et al, 2021, Coleman, 2022, Yde Ohki et al, 2023 to study the mechanisms underlying complex genetic conditions.…”
Section: Introductionmentioning
confidence: 99%
“…Induced pluripotent stem cells (iPSCs) may provide better cell models due to their ability to differentiate into a wide range of cell types and unlimited growth in vitro. They have been used to study many inherited conditions in humans (Mae et al, 2023, Fear et al, 2023, Gorashi et al, 2023 and are of particular value when access to the affected cell types is limited and/or the cells do not expand well in culture (Pereira et al, 2023). More recently human iPSCs have been used in conjunction with polygenic risk scores (Dobrindt et al, 2021, Coleman, 2022, Yde Ohki et al, 2023 to study the mechanisms underlying complex genetic conditions.…”
Section: Introductionmentioning
confidence: 99%