Modeling drug release from a layered double hydroxide–ibuprofen complex

Rojas, Ricardo; Palena, María Celeste; Jiménez-Kairuz, Álvaro F.; Manzo, Rubén H.; Giacomelli, Carla E.

doi:10.1016/j.clay.2012.04.004

Cited by 83 publications

(75 citation statements)

References 30 publications

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“…7,8 Rojas et al studied the drug release from LDHs using ibuprofen as a model drug in an intestinalsimulated PBS solution of pH 6.8 and a gastric-simulated solution (HCl in 0.05 mol⋅L −1 NaCl) of pH 1.2. 176 They found the release at pH 6.8 was relatively similar with PBS 4.8 lysosomal pH. However, release in the gastric environment at pH 1.2 was much faster, such that the complete release took only about 200 minutes.…”

mentioning

confidence: 98%

“…The drug release from inorganic nanolayers (LDHs/LHS) can be tuned for the desired applications, such as for delivery of the drug in a two-phase manner, initially fast followed by a slower release. 37,176 The ability of inorganic nanolayers to protect, release in the desired manner, and release at the target site would avoid the physicochemical degradation of the drug, with a reduction in adverse effects and dosing concentration and frequency, …”

Section: Sustained Release From Inorganic Nanolayersmentioning

confidence: 99%

“…However, release in the gastric environment at pH 1.2 was much faster, such that the complete release took only about 200 minutes. 176 The dissimilar pattern of drug release from LDHs in unlike conditions is due to different release mechanisms. The drug can be released in two different ways: 1) an ion-exchange mechanism and 2) weathering mechanisms.…”

mentioning

confidence: 99%

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Inorganic nanolayers: structure, preparation, and biomedical applications

Saifullah¹,

Hussein²

2015

IJN

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Hydrotalcite-like compounds are two-dimensional inorganic nanolayers also known as clay minerals or anionic clays or layered double hydroxides/layered hydroxy salts, and have emerged as a single type of material with numerous biomedical applications, such as drug delivery, gene delivery, cosmetics, and biosensing. Inorganic nanolayers are promising materials due to their fascinating properties, such as ease of preparation, ability to intercalate different type of anions (inorganic, organic, biomolecules, and even genes), high thermal stability, delivery of intercalated anions in a sustained manner, high biocompatibility, and easy biodegradation. Inorganic nanolayers have been the focus for researchers over the last decade, resulting in widening application horizons, especially in the field of biomedical science. These nanolayers have been widely applied in drug and gene delivery. They have also been applied in biosensing technology, and most recently in bioimaging science. The suitability of inorganic nanolayers for application in drug delivery, gene delivery, biosensing technology, and bioimaging science makes them ideal materials to be applied for theranostic purposes. In this paper, we review the structure, methods of preparation, and latest advances made by inorganic nanolayers in such biomedical applications as drug delivery, gene delivery, biosensing, and bioimaging.

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mentioning

confidence: 98%

Section: Sustained Release From Inorganic Nanolayersmentioning

confidence: 99%

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Inorganic nanolayers: structure, preparation, and biomedical applications

Saifullah¹,

Hussein²

2015

IJN

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“…35 The results of the antimicrobial testing using growth kinetics showed that the nanocomposites have antibacterial activity against Gram-positive bacteria, Gram-negative bacteria, and C. albicans, as is shown in Figure 8A and B. The additional antibacterial activity of the nanocomposites compared to the free INH, which lacks antimicrobial activity, is advantageous in the treatment of polymicrobial infections that may be associated with TB infections.…”

Section: Anti-tb and Antimicrobial Activitiesmentioning

confidence: 99%

“…At a lower pH of 4.8, a slight acidic condition, the drug is released by ion exchange and weathering (degradation) of the LDHs; however at pH 7.4, in alkaline conditions, the release was purely governed by ion exchange. 35,36 The initial, faster release is relative, and the overall release is shorter at a lower pH of 4.8, compared to the release at higher pH values, due to the weathering phenomenon in acidic pH. The LDHs are basic in nature and therefore are stable at pH higher than 7; therefore, release in a basic pH of 7.4 is more sustained as the drug is released by an ion exchange phenomenon and not by weathering of the LDHs -consequently, the release is more sustained at a more basic pH.…”

Section: Particle Size Analysismentioning

confidence: 99%

Synthesis, characterization, and efficacy of antituberculosis isoniazid zinc aluminum-layered double hydroxide based nanocomposites

Saifullah¹,

Zowalaty²,

Arulselvan³

et al. 2016

IJN

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The chemotherapy for tuberculosis (TB) is complicated by its long-term treatment, its frequent drug dosing, and the adverse effects of anti-TB drugs. In this study, we have developed two nanocomposites (A and B) by intercalating the anti-TB drug isoniazid (INH) into Zn/Al-layered double hydroxides. The average size of the nanocomposites was found to bê164 nm. The efficacy of the Zn/Al-layered double hydroxides intercalated INH against Mycobacterium tuberculosis was increased by approximately three times more than free INH. The nanocomposites were also found to be active against Gram-positive and -negative bacteria. Compared to the free INH, the nanodelivery formulation was determined to be three times more biocompatible with human normal lung fibroblast MRC-5 cells and 3T3 fibroblast cells at a very high concentration of 50 µg/mL for up to 72 hours. The in vitro release of INH from the Zn/Al-layered double hydroxides was found to be sustained in human body-simulated buffer solutions of pH 4.8 and 7.4. This research is a step forward in making the TB chemotherapy patient friendly.

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