Modeling enamel matrix secretion in mammalian teeth

Häkkinen, Teemu J.; Sova, Susanna; Corfe, Ian J.; Tjäderhane, Leo; Hannukainen, Antti; Jernvall, Jukka

doi:10.1101/525162

Cited by 8 publications

(11 citation statements)

References 29 publications

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“…6,15 The ideal approach to remineralisation is to reconstruct HA crystals, which are the inorganic component of enamel, typically via the application of fluorides. 19 Clinically applied fluorinated varnish adheres to the enamel surface and creates a CaF 2 layer, which constitutes a physical barrier against acid-related changes. 25,26 However, studies evaluating the effect of fluorides on remineralisation have revealed limitations in the ability of fluoride ions alone to explain the enamel response to acidic attacks.…”

Section: Discussionmentioning

confidence: 99%

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Evaluation of the effects of different remineralisation agents on initial enamel lesions by scanning electron microscope and energy‐distributed X‐ray analysis

Kiliç

Gürbüz

2021

Int J Clin Pract

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The progression of initial enamel lesions can largely be prevented by early diagnosis and treatment, which aim to protect tooth enamel and dentin. 1 The hard tissues of the teeth are affected by changes in acidity within the oral environment. When the pH falls below 5.5, calcium (Ca) and phosphate (P) ions in the enamel structure migrate away from the tooth tissue, leading to a destructive process known as demineralisation. Without efforts to control the acidification of the oral environment, tooth destruction continues, causing the enamel tissue to soften and become porous. 2 Gradually, caries begin to appear on the tooth surface. Initial enamel lesions occur in the earliest stage of decay; at this stage, caries formation is restricted to the enamel and progression thereof can be prevented with appropriate treatments. 3,4 However, when demineralisation is permitted to continue, it begins to affect the dentin layer. Remineralisation of dentin is not possible after caries formation. 5 There is an important balance between demineralisation and remineralisation processes. Increased demineralisation leads to caries progression, 3 while increased remineralisation leads to caries repair. Prophylactic application of

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Section: Discussionmentioning

confidence: 99%

“…Enamel is 87.1% inorganic substances, 11.5% water and 1.4% organic substances. 19 CPP-ACP, fluoride-containing CPP-ACP, HA,…”

mentioning

confidence: 99%

Evaluation of the effects of different remineralisation agents on initial enamel lesions by scanning electron microscope and energy‐distributed X‐ray analysis

Kiliç

Gürbüz

2021

Int J Clin Pract

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“…Despite understanding the heritability of some aspects of dental morphology, 91,92 we have no understanding of the heritability of biomechanically relevant aspects of molar occlusal morphology and how it relates to EDJ shape and/or enamel secretion patterns in primates. 93 This is necessary to construct evolutionary models to (a) understand how selection is acting on dental topography and (b) perform more accurate dietary reconstructions, by understanding how long it takes teeth to become adapted to diet. Here, the biggest challenge lies in gaining a pedigreed collection of unworn dental molds: worn teeth cannot be used for these purposes, as their shape is a product of genetic and environmental factors.…”

Section: Heritabilitymentioning

confidence: 99%

The landscape of tooth shape: Over 20 years of dental topography in primates

Berthaume

Lazzari

Guy

2020

Evolutionary Anthropology

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Diet plays an incontrovertible role in primate evolution, affecting anatomy, growth and development, behavior, and social structure. It should come as no surprise that a myriad of methods for reconstructing diet have developed, mostly utilizing the element that is not only most common in the fossil record but also most pertinent to diet: teeth. Twenty years ago, the union of traditional, anatomical analyses with emerging scanning and imaging technologies led to the development of a new method for quantifying tooth shape and reconstructing the diets of extinct primates. This method became known as dental topography.

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“…The unified models described above are not exhaustive, and do not account for a number of other events experimentally shown to contribute to pattern formation. Tissue growth, for instance, was modelled in studies of mouse digit and teeth patterns [ 41 , 48 , 56 , 57 ] or periodic stripes in zebra fish tailfins [ 58 , 59 ], but reciprocal interactions between molecular, cellular, and mechanical mechanisms remain absent from most models. For example, all known cellular and molecular markers of follicle differentiation, from cell proliferation to the fluctuation of molecular expression, may be generated or affected by intrinsic mechanical properties of the cutaneous tissue.…”

Section: Designing Numerical Evo-devo Approaches To Study Tissue Mmentioning

confidence: 99%

A “Numerical Evo-Devo” Synthesis for the Identification of Pattern-Forming Factors

Bailleul

Manceau

Touboul

2020

Cells

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Animals display extensive diversity in motifs adorning their coat, yet these patterns have reproducible orientation and periodicity within species or groups. Morphological variation has been traditionally used to dissect the genetic basis of evolutionary change, while pattern conservation and stability in both mathematical and organismal models has served to identify core developmental events. Two patterning theories, namely instruction and self-organisation, emerged from this work. Combined, they provide an appealing explanation for how natural patterns form and evolve, but in vivo factors underlying these mechanisms remain elusive. By bridging developmental biology and mathematics, novel frameworks recently allowed breakthroughs in our understanding of pattern establishment, unveiling how patterning strategies combine in space and time, or the importance of tissue morphogenesis in generating positional information. Adding results from surveys of natural variation to these empirical-modelling dialogues improves model inference, analysis, and in vivo testing. In this evo-devo-numerical synthesis, mathematical models have to reproduce not only given stable patterns but also the dynamics of their emergence, and the extent of inter-species variation in these dynamics through minimal parameter change. This integrative approach can help in disentangling molecular, cellular and mechanical interaction during pattern establishment.

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Modeling enamel matrix secretion in mammalian teeth

Abstract: 22 39 matrix deposition can be used to predict occlusal morphologies of teeth. 40 41

Cited by 8 publications

References 29 publications

Evaluation of the effects of different remineralisation agents on initial enamel lesions by scanning electron microscope and energy‐distributed X‐ray analysis

Evaluation of the effects of different remineralisation agents on initial enamel lesions by scanning electron microscope and energy‐distributed X‐ray analysis

The landscape of tooth shape: Over 20 years of dental topography in primates

A “Numerical Evo-Devo” Synthesis for the Identification of Pattern-Forming Factors

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