Modeling for Taxol® Separation in a simulated moving bed

Abstract

ABSTRACT

Taxol® Separation in a Simulated Moving Bed

“…The β values are determined from a pseudo-binary model, in which mixtures A and B are treated as single solutes A and B (Cremasco & Starquit, 2010). The four β values can be estimated from simple material balances around zones and mixing points.…”

“…In order to obtain this mathematical model, some assumptions must be made: the flow rates are constant in each zone; the transversal cross section is constant for and through column; radial dispersion can be neglected; the axial dispersion coefficient is a function of solute and flow rate; the external mass transfer resistance is considered; solid phase is composed of small spheres of uniform radius; the mobile phase is a dilute solution, so that Henry's law can be used to describe the sorbate uptake; the pore diffusion model describes the intraparticle transport mechanism; no chemical reaction occurs; initial concentration inside the column is zero. Based on the previous hypotheses, the adsorption process can be described by the following set of equations, for each solute in each column (Cremasco et al 2009a, Cremasco & Starquit, 2010. ( )…”

“…Figure 3 represents the standing wave approach for multicomponent system. In this figure, A, means low-affinity mixture; B, high-affinity (Cremasco & Starquit, 2010). Fig.…”

“…Researchers around the world have particular attention in the study of natural products as possible source of antineoplasic agents. Due to the diversity of the chemical structures founded in theses products, there are big chances to identify news molecules with anti-tumor activities (Cremasco & Starquit, 2010). The Taxol® (commercial name for Paclitaxel) discovery offers good points for this reasoning (Holanda et al, 2008).…”

“…In a traditional SMB system, a series of fixed bed columns is connected to form a circuit ( Figure 2). (Cremasco & Starquit, 2010) This circuit is divided into four zones by two inlet ports (feed and a solvent) and two outlet ports (a raffinate port, where the low-affinity mixture A is removed, and an extract port, where a high-affinity mixture B is removed). The inlet and outlet ports are periodically moved along the solvent flow direction by multiple-position valves, causing an apparent countercurrent movement between the liquid and the solid phase.…”