Modeling Human Diabetic Kidney Disease by Combining Hyperglycemia and Hypertension in a Transgenic Rodent Model

Therapeutic effects of lisinopril and empagliflozin in a mouse model of hypertension-accelerated diabetic kidney disease

“…Kidney injury was attenuated in db/db UNx-ReninAAV mice following longterm combination treatment with lisinopril and empagliflozin. The clear pathological hallmarks of DKD and therapeutic response to standard of medical care highlight the suitability of the db/db UNx-ReninAAV mouse model for characterizing novel drug therapies for DKD in the setting of T2D and hypertension.Chronic hypertension induced by overexpression of renin, independent from intrinsic homeostatic feedback mechanisms, represents emerging models of DKD(6,18,23). A promising model of progressive DKD has recently been established by AAV-delivery of renin superimposed on baseline kidney disease in diabetic db/db UNx mice(21).…”