“…GAs are highly relevant for industrial applications, because they can handle problems with nonlinear constraints, multiple objectives, and dynamic components -properties that frequently occur in real-life problems (20,25). GA have been successfully applied in a number of areas (2,5,12,31) and still find increasing acceptance; they are often employed as an alternative optimization tool to the conventional methods (20). the effectiveness and robustness of GAs have already been demonstrated in fed-batch cultivation processes (8,32,33,34,35,36,39).…”