Modeling Learning Patterns to Predict Placebo Analgesic Effects in Healthy and Chronic Orofacial Pain Participants

Wang, Yan; Tricou, Christina; Raghuraman, Nandini; Akintola, Titilola; Haycock, Nathaniel R.; Blasini, Maxie; Phillips, Jane; Zhu, Shijun; Colloca, Luana

doi:10.3389/fpsyt.2020.00039

Cited by 10 publications

(17 citation statements)

References 45 publications

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“…Nevertheless, the methodology employed here has repeatedly proven successful in inducing placebo effects in the past 5,26,43 .. Nevertheless, other studies of comparable sample size have reported larger placebo effects 19,20 . It is therefore possible that the correlation analysis for nocebo responses was more successful because of the higher effect sizes.…”

Section: Discussionmentioning

confidence: 76%

“…Regarding predictors for nocebo responses, a relationship with dispositional pessimism 14 , and neuroticism 18 has been reported. In general, placebo effects have received far more attention than nocebo effects 7 , including recent studies involving large cohorts 19,20 . However, the importance of nocebo effects for quality of life, medication adherence and ultimately treatment success are being increasingly acknowledged 21 .…”

Section: Introductionmentioning

confidence: 99%

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Association of nocebo hyperalgesia and basic somatosensory characteristics in a large cohort

Feldhaus

Horing

Sprenger

et al. 2020

Preprint

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Medical outcomes are strongly affected by placebo and nocebo effects. Prediction of who responds to such expectation effects has proven to be challenging. Most recent approaches to prediction have focused on placebo effects in the context of previous treatment experiences and expectancies, or personality traits. However, a recent model has suggested that basic somatosensory characteristics play an important role in expectation responses. Consequently, this study investigated not only the role of psychological variables, but also of basic somatosensory characteristics. In this study, 624 participants underwent a placebo and nocebo heat pain paradigm. Additionally, individual psychological and somatosensory characteristics were assessed. While no significant correlations for placebo responses were identified, nocebo responses were correlated with personality traits but also somatosensory characteristics. Importantly, the correlations between somatosensory characteristics and nocebo responses were among the strongest. This study shows that apart from personality traits, basic somatosensory characteristics play an important role in individual nocebo responses, in agreement with the novel idea that nocebo responses result from the integration of top-down expectation and bottom-up sensory information.

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Section: Discussionmentioning

confidence: 76%

Section: Introductionmentioning

confidence: 99%

Association of nocebo hyperalgesia and basic somatosensory characteristics in a large cohort

Feldhaus

Horing

Sprenger

et al. 2020

Preprint

View full text Add to dashboard Cite

show abstract

“…Nevertheless, the methodology employed here has repeatedly proven successful in inducing placebo effects in the past 9,34,44 . Moreover, other studies of comparable sample size have reported larger placebo effects 27,28 . It is therefore possible www.nature.com/scientificreports/ that the scarcity of measures associated with placebo responses was due to their small effect size, and the regression analysis for nocebo responses was more successful because of the higher effect sizes.…”

Section: Discussionmentioning

confidence: 84%

“…Regarding predictors for nocebo responses, a relationship with dispositional pessimism 22 , and neuroticism 26 has been reported. In general, placebo effects have received far more attention than nocebo effects 11 , including recent studies involving large cohorts 27 , 28 . However, the importance of nocebo effects for quality of life, medication adherence and ultimately treatment success are being increasingly acknowledged 14 , 29 .…”

Section: Introductionmentioning

confidence: 99%

Association of nocebo hyperalgesia and basic somatosensory characteristics in a large cohort

Feldhaus

Horing

Sprenger

et al. 2021

Sci Rep

View full text Add to dashboard Cite

Medical outcomes are strongly affected by placebo and nocebo effects. Prediction of who responds to such expectation effects has proven to be challenging. Most recent approaches to prediction have focused on placebo effects in the context of previous treatment experiences and expectancies, or personality traits. However, a recent model has suggested that basic somatosensory characteristics play an important role in expectation responses. Consequently, this study investigated not only the role of psychological variables, but also of basic somatosensory characteristics. In this study, 624 participants underwent a placebo and nocebo heat pain paradigm. Additionally, individual psychological and somatosensory characteristics were assessed. While no associations were identified for placebo responses, nocebo responses were associated with personality traits (e.g. neuroticism) and somatosensory characteristics (e.g. thermal pain threshold). Importantly, the associations between somatosensory characteristics and nocebo responses were among the strongest. This study shows that apart from personality traits, basic somatosensory characteristics play an important role in individual nocebo responses, in agreement with the novel idea that nocebo responses result from the integration of top-down expectation and bottom-up sensory information.

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“…Of the 23 studies included (Table 1), nine studies used the Diagnostic Criteria for TMD (DC/TMD) to diagnose TMDm 25–34 10,35–47 .…”

Section: Resultsmentioning

confidence: 99%

Evidence for alterations to dynamic quantitative sensory tests in patients with chronic temporomandibular myalgia: A systematic review of observational studies with meta‐analysis

Cayrol

Aron

Gatto

et al. 2022

J of Oral Rehabilitation

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Background Conflicting results exist between somatosensory profiles of patients with temporomandibular myalgia (TMDm). The objective of this review was to examine whether adults with TMDm show altered responses to dynamic quantitative sensory tests compared with healthy controls. Methods We searched five electronic databases for studies, excluding those without suitable controls or where TMDm was associated with confounding non‐musculoskeletal disorders. Risk of bias was assessed with the SIGN case‐control study checklist. Findings were structured around dynamic quantitative sensory tests and their localization. Where possible, we performed meta‐analysis with a random inverse variance model to compare patients with TMDm and healthy controls. Statistical heterogeneity was estimated with Chi² test and inconsistency index, I². Results We extracted data from 23 studies comprising 1284 adults with chronic TMDm and 2791 healthy controls. Risk of bias was assessed as high for 20 studies. Mechanical temporal summation, the most studied phenomenon (14 studies), is increased in the upper limb of patients with TMDm (SMD = 0.43; 95% CI: .11 to .75; p = .009) but not in the jaw area (p = .09) or in the cervical area (p = .29). Very little evidence for altered thermal temporal summation (five studies), conditioned pain modulation (seven studies), exercise‐induced hypoalgesia (two studies), placebo analgesia (two studies), stress‐induced hypoalgesia (one study) and offset analgesia (one study) was found. Discussion A major limitation of this review was the risk of bias of included studies. Future studies would benefit from following methodological guidelines and consideration of confounding factors.

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Modeling Learning Patterns to Predict Placebo Analgesic Effects in Healthy and Chronic Orofacial Pain Participants

Abstract: knowledge can be used to enhance clinical pain outcomes, as chronic pain patients with greater prior experiences of pain reduction may benefit more from placebo analgesia.

Cited by 10 publications

References 45 publications

Association of nocebo hyperalgesia and basic somatosensory characteristics in a large cohort

Association of nocebo hyperalgesia and basic somatosensory characteristics in a large cohort

Association of nocebo hyperalgesia and basic somatosensory characteristics in a large cohort

Evidence for alterations to dynamic quantitative sensory tests in patients with chronic temporomandibular myalgia: A systematic review of observational studies with meta‐analysis

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