Modeling, molecular dynamics and docking studies of a full-length <i>Echinococcus granulosus</i> 2DBD nuclear receptor

Cancela, Saira; Esteves, Adriana; Alvite, Gabriela; Paulino, Margot

doi:10.1080/07391102.2021.2023641

Cited by 6 publications

(2 citation statements)

References 41 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Recently, molecular docking studies showed that unsaturated long-chain fatty acids, in particular oleic, linoleic, and arachidonic acids, are the Eg2DBDα.1 preferred ligands [89]. It is worth mentioning that this ligand's preference is similar to that of the EgFABP1 protein, previously characterized and studied by our research group [90,91].…”

Section: New Subfamilymentioning

confidence: 78%

Perspective Chapter: Parasitic Platyhelminthes Nuclear Receptors as Molecular Crossroads

Esteves¹,

Alvite²

2022

Parasitic Helminths and Zoonoses - From Basic to Applied Research

Self Cite

View full text Add to dashboard Cite

Thanks to the increasing availability of the parasitic Platyhelminthes genomes in recent years, several studies have been directed to the identification of the nuclear receptors set expressed by these organisms. Nevertheless, important gaps in our knowledge remain to be addressed, concerning their mechanism of action, ligands, co-regulator proteins, and DNA binding sequences on target genes. The proposed review chapter will be an account of research into the nuclear receptors field of parasitic Platyhelminthes. Several in vitro effects of host steroid hormones on Taenia and Echinococcus species were observed, however, the classical mammalian estrogen, androgen, or progesterone receptors could not be identified in databases. Nonetheless, novel nuclear receptors and related proteins and genes, are being identified and characterized. The elucidation of their target genes as well as ligands in parasitic Platyhelminthes could allow discovery of new and specific pathways differing from those of their hosts. In this sense, these parasitic proteins seem to be good putative targets of new drugs.

show abstract

Section: New Subfamilymentioning

confidence: 78%

Perspective Chapter: Parasitic Platyhelminthes Nuclear Receptors as Molecular Crossroads

Esteves¹,

Alvite²

2022

Parasitic Helminths and Zoonoses - From Basic to Applied Research

Self Cite

View full text Add to dashboard Cite

show abstract

“…Nonetheless, the investigation into hub genes presents a promising avenue for translational research, potentially informing the development of novel therapeutic or control strategies against E. granulosus . A pertinent example is the work of Cancela et al [ 39 ], who identified a novel subfamily of nuclear receptors with two DNA-binding domains (2DBDs)—a feature not yet reported in vertebrates. Their elucidation of the full-length 3D structure of the, Eg2DBDα.1 nuclear receptor in E. granulosus offers valuable insights into the receptor and structure-function relationship, highlighting its potential as a target for novel anthelmintic drugs.…”

Section: Discussionmentioning

confidence: 99%

Weighted gene co-expression network analysis reveals immune evasion related genes in Echinococcus granulosus sensu stricto

Pereira,

Paludo,

Hidalgo

et al. 2024

Exp. Biol. Med.

View full text Add to dashboard Cite

Cystic echinococcosis (CE) is a zoonotic disease caused by the tapeworm Echinococcus granulosus sensu lato (s.l). In the intermediate host, this disease is characterized by the growth of cysts in viscera such as liver and lungs, inside of which the parasite develops to the next infective stage known as protoscoleces. There are records that the infected viscera affect the development and morphology of E. granulosus s.l. protoscolex in hosts such as buffalo or humans. However, the molecular mechanisms that drive these differences remains unknown. Weighted gene co-expression network analysis (WGCNA) using a set of RNAseq data obtained from E. granulosus sensu stricto (s.s.) protoscoleces found in liver and lung cysts reveals 34 modules in protoscoleces of liver origin, of which 12 have differential co-expression from protoscoleces of lung origin. Three of these twelve modules contain hub genes related to immune evasion: tegument antigen, tegumental protein, ubiquitin hydrolase isozyme L3, COP9 signalosome complex subunit 3, tetraspanin CD9 antigen, and the methyl-CpG-binding protein Mbd2. Also, two of the twelve modules contain only hypothetical proteins with unknown orthology, which means that there are a group of unknown function proteins co-expressed inside the protoscolex of liver CE cyst origin. This is the first evidence of gene expression differences in protoscoleces from CE cysts found in different viscera, with co-expression networks that are exclusive to protoscoleces from liver CE cyst samples. This should be considered in the control strategies of CE, as intermediate hosts can harbor CE cysts in liver, lungs, or both organs simultaneously.

show abstract

Dimerization, host-parasite communication and expression studies of an Echinococcus granulosus 2DBD nuclear receptor

Blanco,

Mozzo,

Alvite

2023

Parasitol Res

View full text Add to dashboard Cite

Modeling, molecular dynamics and docking studies of a full-length Echinococcus granulosus 2DBD nuclear receptor

Cited by 6 publications

References 41 publications

Perspective Chapter: Parasitic Platyhelminthes Nuclear Receptors as Molecular Crossroads

Perspective Chapter: Parasitic Platyhelminthes Nuclear Receptors as Molecular Crossroads

Weighted gene co-expression network analysis reveals immune evasion related genes in Echinococcus granulosus sensu stricto

Dimerization, host-parasite communication and expression studies of an Echinococcus granulosus 2DBD nuclear receptor

Contact Info

Product

Resources

About