This paper presents the design of a high performance Regulated Telescopic Operational Transconductance Amplifier (OTA) for low power and high speed sigma-delta modulator for Mobile WiMAX Applications. Indeed, the Regulated Telescopic OTA is an enhanced DC gain Telescopic circuit with the gate voltage of the cascode transistor is controlled by a feedback amplifier. An algorithmic driven methodology is developed ending to the optimal transistor geometries. Moreover, the proposed OTA was post-layout simulated for some process corners, temperature variation and Monte-Carlo analysis. The post-layout simulation results have achieved a DC gain of 66dB, a large GBW of 862MHz with a phase margin of 58degrees with only 6.24mW power consumption. In addition, the use of a robust Bisquare Weights (BW) method is investigated to predict the Regulated Telescopic OTA performance for new generation systems. Then, the impact of Nanometer CMOS on Regulated Telescopic OTA design is highlighted. It shows the potentialities of future CMOS processes to provide high speed and high performance OTA circuit.