Modeling of adsorption and release kinetics of methotrexate from thermo/magnetic responsive CoFe2O4–BaTiO3, CoFe2O4–Bi4Ti3O12 and Fe3O4–BaTiO3 core-shell magnetoelectric nanoparticles functionalized with PNIPAm

Casillas-Popova, Sofía Nieves; Bernad‐Bernad, María Josefa; Gracia-Mora, Jesús

doi:10.1016/j.jddst.2022.103121

Cited by 6 publications

(3 citation statements)

References 61 publications

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“…Furthermore, MTX interparticle‐confined led in an incomplete release at temperatures below or above the lowest critical solution temperature of PNIPAM. [ 206 ] In another study, core–shell magnetoelectric cobalt ferrite@BaTiO 3 nanocarriers with colloidal stability have been synthesized and conjugated with anticancer drugs (DOX and MTX) with up to 80% functionalization via EDC chemistry. Under external magnetic field of 5 mT, magnetoelectric nanocarriers showed significant improved cytotoxicity to human hepatocellular carcinoma (HepG2) and human malignant melanoma (HT144) as compared to drug‐free or without field repetitions.…”

Section: Batio3 Nanoparticles‐based Nanocomposites and Their Applicat...mentioning

confidence: 99%

A Comprehensive Review on Barium Titanate Nanoparticles as a Persuasive Piezoelectric Material for Biomedical Applications: Prospects and Challenges

Sood

Desseigne

Dev

et al. 2022

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Stimulation of cells with electrical cues is an imperative approach to interact with biological systems and has been exploited in clinical practices over a wide range of pathological ailments. This bioelectric interface has been extensively explored with the help of piezoelectric materials, leading to remarkable advancement in the past two decades. Among other members of this fraternity, colloidal perovskite barium titanate (BaTiO3) has gained substantial interest due to its noteworthy properties which includes high dielectric constant and excellent ferroelectric properties along with acceptable biocompatibility. Significant progression is witnessed for BaTiO3 nanoparticles (BaTiO3 NPs) as potent candidates for biomedical applications and in wearable bioelectronics, making them a promising personal healthcare platform. The current review highlights the nanostructured piezoelectric bio interface of BaTiO3 NPs in applications comprising drug delivery, tissue engineering, bioimaging, bioelectronics, and wearable devices. Particular attention has been dedicated toward the fabrication routes of BaTiO3 NPs along with different approaches for its surface modifications. This review offers a comprehensive discussion on the utility of BaTiO3 NPs as active devices rather than passive structural unit behaving as carriers for biomolecules. The employment of BaTiO3 NPs presents new scenarios and opportunity in the vast field of nanomedicines for biomedical applications.

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Section: Batio3 Nanoparticles‐based Nanocomposites and Their Applicat...mentioning

confidence: 99%

A Comprehensive Review on Barium Titanate Nanoparticles as a Persuasive Piezoelectric Material for Biomedical Applications: Prospects and Challenges

Sood

Desseigne

Dev

et al. 2022

Small

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“…He showed how some of the nanoparticles detected in the target region compare to a current when d.c current is applied (Chauhan, 2022); (Lakshani Randitha, 2018). Many biological systems already have redox potential gradients in their intracellular and extracellular environments, thus if we use a weak redox conductive substance as a nanocarrier like DDS the efficiency (Casillas-Popova et al, 2022).…”

Section: Zwitterionic Polymersmentioning

confidence: 99%

Nanotechnology: optimal applications in anti-cancer drug medicine treatment and diagnosis

Al-saidi¹,

Hadi²,

Hadi³

2023

Bio. Jour.

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The scientific field devoted the importance of studying nanotechnology, which characterizes nanoparticles and their multi-purpose functions, especially nanomedicine techniques. The review focused on newer technologies in biomedical applications as a drug vector in cancer treatment. To occupy the center stage on most of the biological vectors of drugs for the treatment of cancer. Practically, chemical treatments have harm as they target cancerous and non-cancerous cells alike, the solubility is almost non-existent, and the inability of chemotherapy to penetrate cancerous cells, which opens the way for this technique with clear prospects for the aforementioned purpose. The ability to selectively deliver nano-drugs to targeted cancer cells in an optimal manner and to avoid non-specific interactions with healthy cells. The current review focuses on ways to improve the size, shape, and properties of nanomaterials that can be exploited in cancer therapy. The successful treatment of nanocarriers for cancer can be designed for the future as nanotherapies.

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“…Currently, ME nanoparticles decorated with bioactive compounds have been used for different applications, such as ondemand drug delivery (Abdelazim, 2017;Mhambi et al, 2021;Shahzad et al, 2021;Casillas-Popova et al, 2022;Song et al, 2022), nano-electroporation (Kaushik et al, 2017), and brain stimulation (Yue et al, 2012;Kozielski et al, 2021). More specifically, numerical simulation studies (Guduru et al, 2018;Bok et al, 2022) have highlighted that ME materials can operate as enablers for a detailed mapping of the brain, since they generate a magnetic moment when in proximity with a neuron firing its action potential, thus performing a "sensing-type" of read out ("inverse" magnetoelectric effect).…”

Section: Introductionmentioning

confidence: 99%

Magnetoelectric nanoparticles shape modulates their electrical output

Marrella,

Suarato,

Fiocchi

et al. 2023

Front. Bioeng. Biotechnol.

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Core-shell magnetoelectric nanoparticles (MENPs) have recently gained popularity thanks to their capability in inducing a local electric polarization upon an applied magnetic field and vice versa. This work estimates the magnetoelectrical behavior, in terms of magnetoelectric coupling coefficient (αME), via finite element analysis of MENPs with different shapes under either static (DC bias) and time-variant (AC bias) external magnetic fields. With this approach, the dependence of the magnetoelectrical performance on the MENPs geometrical features can be directly derived. Results show that MENPs with a more elongated morphology exhibits a superior αME if compared with spherical nanoparticles of similar volume, under both stimulation conditions analyzed. This response is due to the presence of a larger surface area at the interface between the magnetostrictive core and piezoelectric shell, and to the MENP geometrical orientation along the direction of the magnetic field. These findings pave a new way for the design of novel high-aspect ratio magnetic nanostructures with an improved magnetoelectric behaviour.

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Modeling of adsorption and release kinetics of methotrexate from thermo/magnetic responsive CoFe2O4–BaTiO3, CoFe2O4–Bi4Ti3O12 and Fe3O4–BaTiO3 core-shell magnetoelectric nanoparticles functionalized with PNIPAm

Cited by 6 publications

References 61 publications

A Comprehensive Review on Barium Titanate Nanoparticles as a Persuasive Piezoelectric Material for Biomedical Applications: Prospects and Challenges

A Comprehensive Review on Barium Titanate Nanoparticles as a Persuasive Piezoelectric Material for Biomedical Applications: Prospects and Challenges

Nanotechnology: optimal applications in anti-cancer drug medicine treatment and diagnosis

Magnetoelectric nanoparticles shape modulates their electrical output

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