Modeling of Biological Activity of PEO-Coated Titanium Implants with Conjugates of Cyclic RGD Peptide with Amino Acid Bisphosphonates

Abstract

Titanium is considered to be the most essential metal in the field of implantology. The main factors determining metal biocompatibility, among others, include the morphology and chemical composition of the titanium surface. Therefore, the aim of this work was to develop approaches to control the biological activity of the titanium surface by creating coatings that combine both an inorganic phase with a given morphology and organic molecules containing an integrin-selective peptide that regulate cell adhesion and proliferation. As such, we synthesized new c(RGDfC) derivatives of amino acid bisphosphonates (four examples) with different bisphosphonate anchors and maleimide linkers. These molecules were deposited on a highly developed porous surface obtained via the plasma electrolytic oxidation (PEO) of coarse-grained and nanostructured titanium. In vitro studies demonstrated the increase in the viability degree of mesenchymal stem cells and fibroblasts on the surface of coarse-grained or nanostructured titanium modified with PEO and a c(RGDfC) derivative of ε-aminocaproic acid bisphophonate with an SMCC linker. As a result, the use of conjugates of amino acid bisphosphonates with a cyclic RGD peptide for the modification of PEO-coated titanium opens the ways for the effective control of the biological activity of the metal implant surface.

The Effect of Plasma–Electrolytic Nitrocarburizing of a Medium Carbon Steel Surface on Friction and Wear in Pair with Tin–Lead Bronze

“…If the values of the criterion K p are >1, then plastic contact is realized between the body and the counterbody, regardless of the load [20][21][22][23][24][25]. In our case, the values of the Williamson-Greenwood criterion (8) for all samples after PENC and the raw reference are >1 (Table 1). Thus, the contact is considered plastic and the stress on the contact is taken equal to the hardness, i.e., P r ≈ HB.…”

“…Technologies for plasma-electrolytic treatment have found applications in applying protective ceramic coatings onto the surfaces of metals of the valve group, polishing metal surfaces, and forming hardened diffusion layers on steel and titanium alloys [2][3][4][5][6][7][8][9].…”

Corrosion and Wear Behavior of TiO2/TiN Duplex Coatings on Titanium by Plasma Electrolytic Oxidation and Gas Nitriding

“…When a capacitor is omitted from the circuit, no current can flow because, when the capacitor is charged, the current will not pass, and the circuit will be cut off. The dense oxide layer on the surface of the titanium also has this effect and, such as a capacitor after being fully charge, disrupts the electrical circuit by reducing the corrosion rate [ 52 , 53 , 54 , 55 , 56 , 57 , 58 , 59 , 60 , 61 , 62 , 63 , 64 , 65 , 66 , 67 , 68 , 69 , 70 ]. Based on the EIS diagrams and the obtained data, it can be concluded that the corrosion resistance of the sample with plasma electrolytic oxidation coating is better than that of the uncoated sample.…”

Synthesis and Characterization of Calcium Silicate Nanoparticles Stabilized with Amino Acids

“…In particular, these include colloidal forms of metal silicates, as they have the necessary properties as well as good biological compatibility [ 18 , 19 , 20 , 21 , 22 ]. One can distinguish calcium silicate in the crystalline phase—wollastonite, due to its optimal physicochemical and antibacterial properties, as well as its ability to bind bone tissues [ 23 , 24 , 25 ]. In addition, nanosized calcium silicate is excellent for filling teeth, acting as an effective biologically active material [ 26 , 27 , 28 , 29 , 30 ].…”