Modeling of bone formation and resorption mediated by parathyroid hormone: response to estrogen/PTH therapy

Rattanakul, Chontita; Lenbury, Yongwimon; Krishnamara, Nateetip; Wollkind, David J.

doi:10.1016/s0303-2647(03)00040-6

Cited by 64 publications

(44 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Several published studies were developed by different authors to describe mathematically some cellular aspects of bone remodeling process based on description of BMUs activities without considering the mechanotransduction phase (Rattanakul et al 2003;Lemaire et al 2004;Martin and Buckland-Wright 2004;Komarova 2005;Moroz et al 2006;Maldonado et al 2006;Wimpenny and Moroz 2007;Pivonka et al 2008;Ryser et al 2009). Moreover, bone adaptation models based on considerations of the physiological and biological processes of bone were proposed by (Hart et al 1984;Heaney 1994;Martin 1995).…”

Section: Introductionmentioning

confidence: 99%

Physiologically based mathematical model of transduction of mechanobiological signals by osteocytes

Hambli

Rieger

2011

Biomech Model Mechanobiol

View full text Add to dashboard Cite

Developing mathematical models describing the bone transduction mechanisms, including mechanical and metabolic regulations, has a clear practical applications in bone tissue engineering. The current study attempts to develop a plausible physiologically based mathematical model to describe the mechanotransduction in bone by an osteocyte mediated by the calcium-parathyroid hormone regulation and incorporating the nitric oxide (NO) and prostaglandin E2 (PGE2) effects in early responses to mechanical stimulation. The inputs are mechanical stress and calcium concentration, and the output is a stimulus function corresponding to the stimulatory signal to osteoblasts. The focus will be on the development of the mechanotransduction model rather than investigating the bone remodeling process that is beyond the scope of this study. The different components of the model were based on both experimental and theoretical previously published results describing some observed physiological events in bone mechanotransduction. Current model is a dynamical system expressing the mechanotransduction response of a given osteocyte with zero explicit space dimensions, but with a dependent variable that records signal amplitude as a function of mechanical stress, some metabolic factors release, and time. We then investigated the model response in term of stimulus signal variation versus the model inputs. Despite the limitations of the model, predicted and experimental results from literature have the same trends.

show abstract

Section: Introductionmentioning

confidence: 99%

Physiologically based mathematical model of transduction of mechanobiological signals by osteocytes

Hambli

Rieger

2011

Biomech Model Mechanobiol

View full text Add to dashboard Cite

show abstract

“…Urine excretion has not been individually modeled, but only as a part of the calcium balance model (Hurwitz et al, 1987a;Peterson and Riggs, 2010;Raposo et al, 2002). The bone remodeling process has been modeled as a function of bone cells and their regulators (Komarova, 2005;Komarova et al, 2003;Kroll, 2000;Lemaire et al, 2004;Rattanakul et al, 2003). The model predicted relative changes in bone volume or mass in response to bone cell dynamics.…”

Section: Mechanistic Modeling In Calcium Studiesmentioning

confidence: 99%

Review on Application of Biosystem Modeling: Introducing 3 Model-based Approaches in Studying Ca Metabolism

Lee

Cho²

2012

Journal of Biosystems Engineering

View full text Add to dashboard Cite

Purpose:This review aims at introducing 3 modeling approaches classified into 3 categories based on the purpose (estimation or prediction), structure (linear or non-linear) and phase (steady-state or dynamic-state); 1) statistical approaches, 2) kinetic modeling and 3) mechanistic modeling. We hope that this review can be a useful guide in the model-based approach of calcium metabolism as well as illustrates an application of engineering tools in studying biosystems. Background: The meaning of biosystems has been expanded, including agricultural/food system as well as biological systems like genes, cells and metabolisms. This expansion has required a useful tool for assessing the biosystems and modeling has arisen as a method that satisfies the current inquiry. To suit for the flow of the era, examining the system which is a little bit far from the traditional biosystems may be interesting issue, which can enlarge our insights and provide new ideas for prospective biosystem-researches. Herein, calcium metabolic models reviewed as an example of application of modeling approaches into the biosystems. Review: Calcium is an essential nutrient widely involved in animal and human metabolism including bone mineralization and signaling pathways. For this reason, the calcium metabolic system has been studied in various research fields of academia and industries. To study calcium metabolism, model-based system analyses have been utilized according to the purpose, subject characteristics, metabolic sites of interest, and experimental design. Either individual metabolic pathways or a whole homeostasis has been modeled in a number of studies.

show abstract

“…alkaline phosphatase and osteocalcin in bone cells. Modifies bone remodelling after ovariectomy in close relation with estradiol (Roth et al, 1999;Ladizesky et al, 2001) Parathyroid hormone (PTH) In low dose causes increase in bone density and cancellous/trabecular bone volume without impairing normal bone architecture and has a direct effect on recruitment/proliferation of osteoblasts (Stewart, 1996;Morley et al, 1997;Watson et al, 1998;Mohan et al, 2000;Patton, 2000;Rattanakul et al, 2003;Schneider et al, 2003) Thyroxin Thyroid hormone which stimulates osteoclastic bone resorption (Buckwalter et al, 1996) Cortisol Influences PTH-responsiveness of bone.…”

Section: Growth Factorsmentioning

confidence: 99%

Materials in particulate form for tissue engineering. 2. Applications in bone

Silva

Coutinho

Ducheyne

et al. 2007

J Tissue Eng Regen Med

100

View full text Add to dashboard Cite

Materials in particulate form have been the subjects of intensive research in view of their use as drug delivery systems. While within this application there are still issues to be addressed, these systems are now being regarded as having a great potential for tissue engineering applications. Bone repair is a very demanding task, due to the specific characteristics of skeletal tissues, and the design of scaffolds for bone tissue engineering presents several difficulties. Materials in particulate form are now seen as a means of achieving higher control over parameters such as porosity, pore size, surface area and the mechanical properties of the scaffold. These materials also have the potential to incorporate biologically active molecules for release and to serve as carriers for cells. It is believed that the combination of these features would create a more efficient approach towards regeneration. This review focuses on the application of materials in particulate form for bone tissue engineering. A brief overview of bone biology and the healing process is also provided in order to place the application in its broader context. An original compilation of molecules with a documented role in bone tissue biology is listed, as they have the potential to be used in bone tissue engineering strategies. To sum up this review, examples of works addressing the above aspects are presented. JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE R E V I E W A R T I C L E AbstractMaterials in particulate form have been the subjects of intensive research in view of their use as drug delivery systems. While within this application there are still issues to be addressed, these systems are now being regarded as having a great potential for tissue engineering applications. Bone repair is a very demanding task, due to the specific characteristics of skeletal tissues, and the design of scaffolds for bone tissue engineering presents several difficulties. Materials in particulate form are now seen as a means of achieving higher control over parameters such as porosity, pore size, surface area and the mechanical properties of the scaffold. These materials also have the potential to incorporate biologically active molecules for release and to serve as carriers for cells. It is believed that the combination of these features would create a more efficient approach towards regeneration. This review focuses on the application of materials in particulate form for bone tissue engineering. A brief overview of bone biology and the healing process is also provided in order to place the application in its broader context. An original compilation of molecules with a documented role in bone tissue biology is listed, as they have the potential to be used in bone tissue engineering strategies. To sum up this review, examples of works addressing the above aspects are presented.

show abstract

Modeling of bone formation and resorption mediated by parathyroid hormone: response to estrogen/PTH therapy

Cited by 64 publications

References 25 publications

Physiologically based mathematical model of transduction of mechanobiological signals by osteocytes

Physiologically based mathematical model of transduction of mechanobiological signals by osteocytes

Review on Application of Biosystem Modeling: Introducing 3 Model-based Approaches in Studying Ca Metabolism

Materials in particulate form for tissue engineering. 2. Applications in bone

Contact Info

Product

Resources

About