Modeling of cell sorting and rare cell capture with microfabricated biodevices

Járvás, Gábor; Guttman, András

doi:10.1016/j.tibtech.2013.10.001

Cited by 14 publications

(15 citation statements)

References 58 publications

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“…One of the biggest challenges of CFD‐generated models is the external validation part, which is even more difficult in case of microfabricated structures . Particle tracing methods require a transparent chamber and colored tracer particles to determine the velocities in such a device .…”

Section: Methodsmentioning

confidence: 99%

Tilted pillar array fabrication by the combination of proton beam writing and soft lithography for microfluidic cell capture Part 2: Image sequence analysis based evaluation and biological application

et al. 2017

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Section: Methodsmentioning

confidence: 99%

Tilted pillar array fabrication by the combination of proton beam writing and soft lithography for microfluidic cell capture Part 2: Image sequence analysis based evaluation and biological application

et al. 2017

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“…MCCDs modeling was based on the laminar form of the Navier–Stokes transport equation, since the characteristic size dependent Reynolds number is typically around unity in such microdevices :

ρ (\frac{\partial u}{\partial t} + (u \cdot \nabla) u) = \nabla (- p I + η (\nabla u + {(\nabla u)}^{T})),

where u is the linear velocity, ρ is the fluid density, η is the kinematic fluid viscosity, t is the time, and p is the pressure. Equation should be coupled to the so‐called continuity equation considering incompressible fluids:

\nabla \cdot u = 0 .

…”

Section: Theorymentioning

confidence: 99%

“…MCCDs modeling was based on the laminar form of the Navier-Stokes transport equation, since the characteristic size dependent Reynolds number is typically around unity in such microdevices [13]:…”

Section: Theorymentioning

confidence: 99%

Tilted pillar array fabrication by the combination of proton beam writing and soft lithography for microfluidic cell capture: Part 1 Design and feasibility

et al. 2015

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Design, fabrication, integration, and feasibility test results of a novel microfluidic cell capture device is presented, exploiting the advantages of proton beam writing to make lithographic irradiations under multiple target tilting angles and UV lithography to easily reproduce large area structures. A cell capture device is demonstrated with a unique doubly tilted micropillar array design for cell manipulation in microfluidic applications. Tilting the pillars increased their functional surface, therefore, enhanced fluidic interaction when special bioaffinity coating was used, and improved fluid dynamic behavior regarding cell culture injection. The proposed microstructures were capable to support adequate distribution of body fluids, such as blood, spinal fluid, etc., between the inlet and outlet of the microfluidic sample reservoirs, offering advanced cell capture capability on the functionalized surfaces. The hydrodynamic characteristics of the microfluidic systems were tested with yeast cells (similar size as red blood cells) for efficient capture.

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“…Since nanobiodevices have tremendous advantages, [1][2][3][4][5][6][7] they are applicable to single-cell analysis, [8][9][10] single biomolecular analysis 11,12 and the fast analysis of biomolecules developed by an appropriate small space with a short diffusion distance for cells and biomolecules, which have extremely small diffusion constants. 13 Nanomaterials, such as quantum dots, which have quantum confined effects, are essential to develop highly bright and long-life fluorescence materials, which will be indispensable for molecular imaging 14,15 and in vivo imaging.…”

Section: Introductionmentioning

confidence: 99%

Nanobiodevice-based Single Biomolecule Analysis, Single-Cell Analysis, and in vivo Imaging for Cancer Diagnosis, Cancer Theranostics, and iPS Cell-based Regenerative Medicine

Kaji

Baba

2014

ANAL. SCI.

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Modeling of cell sorting and rare cell capture with microfabricated biodevices

Cited by 14 publications

References 58 publications

Tilted pillar array fabrication by the combination of proton beam writing and soft lithography for microfluidic cell capture Part 2: Image sequence analysis based evaluation and biological application

Tilted pillar array fabrication by the combination of proton beam writing and soft lithography for microfluidic cell capture Part 2: Image sequence analysis based evaluation and biological application

Tilted pillar array fabrication by the combination of proton beam writing and soft lithography for microfluidic cell capture: Part 1 Design and feasibility

Nanobiodevice-based Single Biomolecule Analysis, Single-Cell Analysis, and in vivo Imaging for Cancer Diagnosis, Cancer Theranostics, and iPS Cell-based Regenerative Medicine

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