Modeling of cellular pearl chain formation using a double photoconductive layer biochip

Hu, Sheng; Zhao, Yong; Yang, Yang

doi:10.1016/j.elstat.2015.08.001

Cited by 6 publications

(3 citation statements)

References 27 publications

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“…The effective dipole moment p i for particle i can be expressed in Eq. (2) [25] as: [8] MST IIM + FDM Ai et al [9,10] MST ALE+FEM Camarda et al [13] P D D S Kang et al [14] MST SIM + FVM Hu et al [15] P D M C Xie et al [16] MST ALE+FEM Xie et al [17,18] IDM FEM Gutierrez et al [19] P D A L E + F E M Liu et al [20,21] IDM FEM Belijar et al [22] P D D S where a i is the radius of particle i, E is the external applied electric field. The parameter f CM is the well-known Clausius-Mossotti (CM) factor, which determines the direction of the DEP force.…”

Section: Theory and Modelmentioning

confidence: 99%

“…In addition, Gutierrez et al [19] proposed a novel numerical model for the help of both the electromagnetism and the solid mechanics modules from COMSOL finite element software, which provided insight into chain formation from such elliptical particles, including size, aspect ratio, and heterogeneity. In contrast to either ALE or IIM numerical models, both dynamics simulation (DS) and Monte Carlo (MC) methods can be used for an overwhelming amount of particles suspended in an aqueous solution [1,15,22]. In our previous work [23], the MC method was used to describe the behavior of carbon nanotubes and their arrangement when the total system energy decreases and becomes stable.…”

Section: Introductionmentioning

confidence: 99%

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Expanding the flexibility of dynamics simulation on different size particle–particle interactions by dielectrophoresis

2018

J Biol Phys

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In this paper, we perform flexible and reliable dynamics simulations on different sizes of two or more particles' interactive motions, where they encounter positive or negative dielectrophoresis (DEP) forces. The particles with identical or non-identical size are in close proximity suspended freely in a solution under a homogeneous electric field. According to the description of classic dipole moment, DEP forces make the particles form a straight chain. Therefore, dynamics simulation based on Newton's laws is utilized to understand AC DEP phenomena among multiple particles. To solve the relevant governing equations, Stokes drag and repulsive forces (including wall and particles) are combined with DEP forces to obtain the trajectories of particles. Results show that particles with the same sign of the Clausius-Mossotti (CM) factor revolve clockwise or counterclockwise to attract each other parallel to the electric field direction. Conversely, the particle chain is perpendicular to the field. This programmable advantage is of great benefit to the study of three or four particle motions. Meanwhile, the pearl chain consisting of three or four particles is related not only to an individual CM factor but also to initial spatial configuration. Both the cluster and short chain are dependent on symmetry between the geometric distribution and electric field, while it implies different size particles easily cause the chain structure with less time.

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Section: Theory and Modelmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Expanding the flexibility of dynamics simulation on different size particle–particle interactions by dielectrophoresis

2018

J Biol Phys

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“…Particle manipulation has become increasingly crucial in diverse areas of medicine and biotechnology in recent times * Author to whom any correspondence should be addressed. [1][2][3][4]. Recent research has focused on developing nano and microsystems that utilize electrokinetic forces for particle manipulation [5][6][7].…”

Section: Introductionmentioning

confidence: 99%

A novel micro-device for simultaneous separation-trapping and double-trapping of particles by using dielectrophoresis: numerical and experimental study

Aghdasi,

Nazari,

Yonesi

2023

J. Micromech. Microeng.

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Dielectrophoretic (DEP) force is a useful tool for manipulating particles in microfluidic systems. It is affected by the frequency of the applied electric field, which can be varied to produce repellent and attractive forces depending on the dielectric properties of particles and the media. In this work, two electric fields with different frequency are used to simultaneously separate and trap particles as well as double-trap particles by utilizing the DEP force. Initially, a single-vial microchannel was proposed to study the impact of the frequency and voltage on three types of electrodes: concentrator, repellent, and absorbing. The goal was to examine their efficacy in trapping a group of particles within the vial while separating and ejecting another group of particles from the microchannel. Performance graphs were used to determine the optimal voltages for the electrodes. Subsequently, an additional vial is incorporated into the microchannel to enable the double-trapping of particles with varying sizes and properties. With the optimal design, particles of varying sizes and properties can be trapped in separate vials within the microchannel. For the first time, the performance cartography of the proposed system has been assessed, enabling the identification of the optimal values and intelligent separations. Validation is conducted in two steps. Firstly, numerical findings are compared to previous experimental results to verify the accuracy of the numerical approach. Secondly, a microchip is fabricated, tested, and compared to numerical results using yeast cells to assess system efficiency and enhance the reliability of the numerical technique.

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Dielectrophoresis based cell switching in continuous flow microfluidic devices

Mathew

Alazzam

Destgeer

et al. 2016

Journal of Electrostatics

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Modeling of cellular pearl chain formation using a double photoconductive layer biochip

Cited by 6 publications

References 27 publications

Expanding the flexibility of dynamics simulation on different size particle–particle interactions by dielectrophoresis

Expanding the flexibility of dynamics simulation on different size particle–particle interactions by dielectrophoresis

A novel micro-device for simultaneous separation-trapping and double-trapping of particles by using dielectrophoresis: numerical and experimental study

Dielectrophoresis based cell switching in continuous flow microfluidic devices

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