In recent decades, connections between concrete-filled steel tubular columns (CFST) and H-steel beams have been well designed and implemented. However, owing to poor construction quality, brittle failure often occurs at weld seams. In this study, an innovative joint was developed to connect CFST columns and H-steel beams using a top-weld bottom-bolt (TWBB) connection to minimize the effect of welding quality on the seismic resistance of joints. Six specimens were designed for cycle-reversed loading tests to discuss the seismic performance of this joint. Four configurations, including different connection methods, beam heights, column forms, and stiffener thicknesses, were considered in the test. The impacts of different configuration forms on the failure mode, strength, stiffness, ductility, and energy dissipation of the specimens were evaluated.The test results demonstrated that the columns with or without concrete had a significant effect on