Climate change is expected to raise river discharge and sea level in the future, and these near-term changes could alter the river flow regime and sedimentation pattern of future floods. Present hazard assessment studies have limitations in considering such morpho-dynamic responses in evaluating flood hazards or risks. Here, we present a multi-model-based approach to quantify such potential hazard parameters influenced by climate change for the most vulnerable communities living on river bars and islands of the Brahmaputra–Jamuna River. River flood-flow and flood wave propagation characteristics are predicted to be affected by changing temporal distribution patterns of precipitation as a result of enhanced global warming. Increased incidences of large multi-peak floods or uncommon floods resulting in long-duration floods driven by sea-level rise may happen as a result of this. To assess it, we have set up a hydromorphic model, Delft3D, for the Brahmaputra–Jamuna River forced by upstream flow, generated from a hydrological model SWAT, over the Brahmaputra basin. The simulations cover moderate, wettest, and driest conditions of the RCP8.5 scenario, and the results reflect the flooding consequences of the near-future, mid-century, and end-century. Floods in the Brahmaputra–Jamuna River are becoming more severe, frequent, and long-lasting, as a result of climate change, and are expected to last until the end of November rather than the current September timeline. While assessing the hazard, we found that the pattern and timing of the flood are as equally important as the peak of the flood, as the river continuously adjusts its cross-sectional area with the flow. The study also demonstrates that, depending on their location/position, climate-induced hazards can affect sand bars/islands disproportionally. The high flood depth, duration, and sedimentation have a significant impact on the sand bars downstream of the river, making them more vulnerable.