Modeling of composite sorption isotherm for stratum corneum

Argatov, Ivan; Engblom, Johan; Kocherbitov, Vitaly

doi:10.1016/j.bbamem.2022.183910

Cited by 2 publications

(1 citation statement)

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“…It was concluded that for describing most of the collected SSWL data, in particular, the value of the GAB parameter k must be reduced similar to earlier microcalorimetry studies of human SC 22 . In this regard it should be highlighted that the sorption isotherm of SC is known to be influenced by its composition, including the lipid content 23 , so that the GAB parameter k is expected to be subject-dependent. In the case under consideration, it has been verified (see SI , Section II , Fig.…”

Section: Resultsmentioning

confidence: 99%

Dynamics of post-occlusion water diffusion in stratum corneum

Argatov

Roosen-Runge

Kocherbitov

2022

Sci Rep

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Diffusion of water through membranes presents a considerable challenge, as the diffusivity often depends on the local concentration of water. One particular example with strong biological relevance is the stratum corneum (SC) as the primary permeability barrier for the skin. A simple alternative for the constant diffusivity model is provided by the Fujita’s two-parameter rational approximation, which captures the experimentally observed fact that the SC diffusion constant for water increases with increasing the water concentration. Based on Fick’s law of diffusion, a one-dimensional concentration-dependent diffusion model is developed and applied for the analysis of both the steady-state transepidermal water loss (TEWL) and the non-steady-state so-called skin surface water loss (SSWL) occurred after removal of an occlusion patch from the SC surface. It is shown that some of the age-related changes in the SSWL can be qualitatively explained by the variation of the dimensionless Fujita concentration-dependence parameter.

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Section: Resultsmentioning

confidence: 99%