Modeling of heat transfer distribution in tumor breast cancer during microwave ablation therapy

Selmi, Marwa; Iqbal, Amjad; Smida, Besma; Waly, Mohamed Ibrahim; Belmabrouk, Hafedh

doi:10.1002/mop.33290

Cited by 4 publications

(2 citation statements)

References 33 publications

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“…Some issues related to blood perfusion have been extensively discussed [34]. In the present study, the Penne's model [35,36] is used.…”

Section: Heat Transfer Fieldmentioning

confidence: 99%

Improved Modeling of Temperature Evolution during Lung Cancer Tumor Thermal Ablation

Selmi

2024

Physics

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Microwave ablation (MWA) represents one of the most powerful tools in cancer treatment. This therapeutic modality process is governed by the temperature and absorbed dose of radiation of the cell tissue. This study was performed to control the temperature effect using simulation during the MWA thermal damage of lung tumor. For this reason, a two-dimensional (2D) computational modeling generated for adaptive lung tissue was designed and analyzed using the finite element method (FEM). Different approaches, such as first-order Arrhenius rate equations, Maxwell equations, and the bioheat equation, have been used to simulate necrosis in cells. To control the heat, a proportional–integral–derivative (PID) controller was used to moderate the input microwave power source and to maintain the temperature of the target tip at a lower level of the initial temperature data. Furthermore, full cancer tissue necrosis was also evaluated by processing time and thermal damage fraction. The obtained data proved that the target tip temperature was affected by the temperature distribution and specific absorption rate (SAR). However, a specific treatment period of tumor ablation is required to control and decrease the damage of surrounding healthy tissue to ensure a safe operation without any risk.

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“…Some issues related to blood perfusion have been extensively discussed [34]. In the present study, the Penne's model [35,36] is used.…”

Section: Heat Transfer Fieldmentioning

confidence: 99%

Improved Modeling of Temperature Evolution during Lung Cancer Tumor Thermal Ablation

Selmi

2024

Physics

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“…In order to achieve a spherical SAR pattern, Etoz and Brace [36] built dual-slot antennas with an 8 mm gap between the slots. Marwa Selmi et al [37] investigated temperature, the influence of the type of antenna on the temperature distribution in the breast tissue, the specific absorption rate, and the amount of necrotic tissue. Rattanadecho and Keangin [10] compared the effects on the SAR profile, temperature, and blood velocity profiles for single-slot and double-slot antennas.…”

Section: Plos Onementioning

confidence: 99%

3D modeling of vector/edge finite element method for multi-ablation technique for large tumor-computational approach

Boregowda

Mariappan

2023

PLoS ONE

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Microwave ablation (MWA) is a cancer thermal ablation treatment that uses electromagnetic waves to generate heat within the tissue. The goal of this treatment is to eliminate tumor cells while leaving healthy cells unharmed. During MWA, excess heat generation can kill healthy cells. Hence, mathematical models and numerical techniques are required to analyze the heat distribution in the tissue before the treatment. The aim of this research is to explain the implementation of the 3D vector finite element method in a wave propagation model that simulates the specific absorption rate in the liver. The 3D Nedelec elements from H(curl; Ω) space are used to discretize the wave propagation model, and this implementation is helpful in solving many real-world problems that involve electromagnetic propagation with perfect conducting and absorbing boundary conditions. One of the difficulties in ablation treatment is creating a large ablation zone for a large tumor (diameter greater than 3 cm) in a short period of time with minimum damage to the surrounding tissue. This article addresses the aforementioned issue by introducing four antennas into the different places of the tumor sequentially and producing heat uniformly over the tumor. The results demonstrated that 95.5% of the tumor cells were killed with minimal damage to the healthy cells when the heating time was increased to 4 minutes at each position. Subsequently, we studied the temperature distribution and localised tissue contraction in the tissue using the three-dimensional bio-heat equation and temperature-time dependent model, respectively. The local tissue contraction is measured at arbitrary points in the domain and is more noticeable at temperatures higher than 102°C. The thermal damage in the liver during MWA treatment is investigated using the three-state cell death model. The system of partial differential equations is solved numerically due to the complex geometry of the domain, and the results are compared with experimental data to validate the models and parameters.

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A polylysine/hyaluronan-based core-shell nanoparticle triggers drug delivery by ATP/hyaluronidase dual stimuli for inducing apoptosis of breast cancer cells

Liu,

Wu,

Deng

et al. 2024

International Journal of Biological Macromolecules

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Modeling of heat transfer distribution in tumor breast cancer during microwave ablation therapy

Cited by 4 publications

References 33 publications

Improved Modeling of Temperature Evolution during Lung Cancer Tumor Thermal Ablation

Improved Modeling of Temperature Evolution during Lung Cancer Tumor Thermal Ablation

3D modeling of vector/edge finite element method for multi-ablation technique for large tumor-computational approach

A polylysine/hyaluronan-based core-shell nanoparticle triggers drug delivery by ATP/hyaluronidase dual stimuli for inducing apoptosis of breast cancer cells

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