Modeling of non-Newtonian blood flow through a stenosed artery incorporating fluid-structure interaction

Chan, Weng Yew; Ding, Yan; Tu, Jiyuan

doi:10.21914/anziamj.v47i0.1059

Cited by 55 publications

(28 citation statements)

References 11 publications

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“…To simulate the blood flow when the voltage is applied, according to Johnston et al [30,31], who compared five different non-Newtonian blood models, the one that best fitted the experimental data was the Carreau model with the following constants:…”

Section: Numerical Hydrodynamic Modelingmentioning

confidence: 99%

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Hydrodynamic and direct-current insulator-based dielectrophoresis (H-DC-iDEP) microfluidic blood plasma separation

et al. 2015

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Evaluation and diagnosis of blood alterations is a common request for clinical laboratories, requiring a complex technological approach and dedication of health resources. In this paper, we present a microfluidic device that owing to a novel combination of hydrodynamic and dielectrophoretic techniques can separate plasma from fresh blood in a microfluidic channel and for the first time allows optical real-time monitoring of the components of plasma without pre- or post-processing. The microchannel is based on a set of dead-end branches at each side and is initially filled using capillary forces with a 2-μL droplet of fresh blood. During this process, stagnation zones are generated at the dead-end branches and some red blood cells (RBCs) are trapped there. An electric field is then applied and dielectrophoretic trapping of RBCs is used to prevent more RBCs entering into the channel, which works like a sieve. Besides, an electroosmotic flow is generated to sweep the rest of the RBCs from the central part of the channel. Consequently, an RBC-free zone of plasma is formed in the middle of the channel, allowing real-time monitoring of the platelet behavior. To study the generation of stagnation zones and to ensure RBC trapping in the initial constrictions, two numerical models were solved. The proposed experimental design separates up to 0.1 μL blood plasma from a 2-μL fresh human blood droplet. In this study, a plasma purity of 99 % was achieved after 7 min, according to the measurements taken by image analysis. Graphical Abstract Schematics of a real-time plasma monitoring system based on a Hydrodynamic and direct-current insulator-based dielectrophoresis microfluidic channel.

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Section: Numerical Hydrodynamic Modelingmentioning

confidence: 99%

“…where λ=3.13s is the time constant, μ is fluid viscosity,γ is strain rate tensor, μ 0 =0.56P is zero strain viscosity (1P=0.1 Ns/m 2 ), μ ∞ = 0.0345P is infinite strain viscosity, and n= 0.3568 is an empirical exponent [30,31].…”

Section: Numerical Hydrodynamic Modelingmentioning

confidence: 99%

Hydrodynamic and direct-current insulator-based dielectrophoresis (H-DC-iDEP) microfluidic blood plasma separation

et al. 2015

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“…A number of non-Newtonian viscosity models are adopted in practice for simulating practical flow problems [23][24][25][26]. To simulate blood flow, models such as the Carreau-Yasuda and power law models have been used [25,26].…”

Section: Non-newtonian Modelmentioning

confidence: 99%

“…To simulate blood flow, models such as the Carreau-Yasuda and power law models have been used [25,26]. Cho and Kensey [27] investigated several non-Newtonian models, including power law and Carreau models, to represent the rheological behaviour of the blood.…”

Section: Non-newtonian Modelmentioning

confidence: 99%

Non‐Newtonian blood flow study in a model cavopulmonary vascular system

Chitra

Sundararajan

Vengadesan

et al. 2011

Numerical Methods in Fluids

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SUMMARYA transient haemodynamic study in a model cavopulmonary vascular system has been carried out for a typical range of parameters using a finite element-based Navier-Stokes solver. The focus of this study is to investigate the influence of non-Newtonian behaviour of the blood on the haemodynamic quantities, such as wall shear stress (WSS) and flow pattern. The computational fluid dynamics (CFD) model is based on an artificial compressibility characteristic-based split (AC-CBS) scheme, which has been adopted to solve the Navier-Stokes equations in space-time domain. A power law model has been implemented to characterize the shear thinning nature of the blood depending on the local strain rate. Using the computational model, numerical investigations have been performed for Newtonian and non-Newtonian flows for different frequencies and input pulse forms. The haemodynamic quantities observed in total cavopulmonary connection (TCPC) for the above conditions suggest that there are considerable differences in average (about 25-40%) and peak (about 50%) WSS distributions, when the non-Newtonian behaviour of the blood is taken into account. The lower WSS levels observed for non-Newtonian cases point to the higher risk of lesion formation, especially at higher pulsation frequencies. A realistic pulse form is relatively safer than a sinusoidal pulse as it has more energy distributed in the higher harmonics, which results in higher average WSS values. The present study highlights the importance of including non-Newtonian shear thinning behaviour for modelling blood flow in the vicinity of repaired arterial connections.

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“…They assumed blood as a Newtonian fluid, studied the flow characteristics such as the velocity and the wall shear stress, and observed that the expansion of the arteries is due to the internal pressure. Chan et al [8] continued Lee and Xu's study [6] , and considered the power law and Carreau non-Newtonian models for the blood flow. Li et al [9] studied the pulsatile blood flow and the vessel wall mechanics with different degrees of stenoses.…”

Section: Introductionmentioning

confidence: 99%

Effects of renal artery stenosis on realistic model of abdominal aorta and renal arteries incorporating fluid-structure interaction and pulsatile non-Newtonian blood flow

Mortazavinia

Zare

Mehdizadeh

2012

Appl. Math. Mech.-Engl. Ed.

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The effects of the renal artery stenosis (RAS) on the blood flow and vessel walls are investigated. The pulsatile blood flow through an anatomically realistic model of the abdominal aorta and renal arteries reconstructed from CT-scan images is simulated, which incorporates the fluid-structure interaction (FSI). In addition to the investigation of the RAS effects on the wall shear stress and the displacement of the vessel wall, it is determined that the RAS leads to decrease in the renal mass flow. This may cause the activation of the renin-angiotension system and results in severe hypertension.

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Modeling of non-Newtonian blood flow through a stenosed artery incorporating fluid-structure interaction

Cited by 55 publications

References 11 publications

Hydrodynamic and direct-current insulator-based dielectrophoresis (H-DC-iDEP) microfluidic blood plasma separation

Hydrodynamic and direct-current insulator-based dielectrophoresis (H-DC-iDEP) microfluidic blood plasma separation

Non‐Newtonian blood flow study in a model cavopulmonary vascular system

Effects of renal artery stenosis on realistic model of abdominal aorta and renal arteries incorporating fluid-structure interaction and pulsatile non-Newtonian blood flow

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