In order to resolve the range and azimuth ambiguity in MIMO-SAR imaging, this paper proposed a joint two-dimensional ambiguity resolving method based on space-time filtering, which according to the ambiguity in different subscene is relative to different nearest echo range, and different azimuth time is relative to different instantaneous incidence angle, to make two-dimensional space-time steering vector for resolving ambiguity of the echo, which also can finish the imaging processing at the same time. Simulation results validate the proposed processing approach for the MIMO-SAR system.