Passive Intermodulation (PIM) is a well-known phenomenon that poses a significant challenge to modern wireless communication systems. Despite efforts to reduce or mitigate PIM through hardware design, frequency planning, and band separation techniques, the impact of PIM on radio performance remains substantial. Particularly, radio transceivers operating in the frequency division duplex mode are known to be susceptible to PIM problems. Moreover, with the adoption of carrier aggregation and advanced multi-antenna technology, PIM is increasingly becoming a major issue in multi-band multi-standard radio systems. Therefore, innovative approaches that exploit PIM detection, avoidance, and cancellation techniques are required to effectively mitigate or reduce its impact. In response to these challenges, this thesis highlights various PIM interference mechanisms and their interactions that can potentially lead to sensitivity degradation. The thesis continues with a discussion of PIM mitigation approaches and underscores the potential of digital PIM cancellation (PIMC) solutions to offer a hardware-independent resolution for reducing PIM impact in multi-band radios in the 5G era and beyond. Two key contributions are presented as follows:2. Dr. Adnan Kiayani of Ericsson AB, Sweden, for his mentorship, technical expertise, and insightful discussions that enriched my understanding of the subject matter. His mentorship has been instrumental in shaping this thesis.3. Thesis supervisor, Chancellor's Professor Halim Yanikomeroglu, for his unwavering support, guidance, and dedication to my academic development.