Modeling of Restenosis on Implanted Intra-Arterial Stent in Experimental Cardiology

Abstract

Aim of investigation is to study the features of the mechanism of restenosis on implanted intravascular stent, using the original device for modeling of intra-arterial circulation. Materials and methods. We use an original device for modeling intra-arterial circulation (document of invention RU 202780). It is a simulation of arterial vessel, made of glass tube rotameter. Its free ends are connected with two silicone tubes, with other ends - to the pump, powered by a 12 Volt battery. We injected the fluid (an aqueous solution of glycerin) into the closed system, diluted corresponding to the viscosity of human blood. A fitting is located at the inlet end of the tube, through which we can introduce a dye (ink), a silk thread or intravascular pressure probe inside the tube. Results. As a prototype of intravascular endoprosthesis, we used a metal device 71 mm length, made in the form of a grid with beams directed in a spiral. We installed a conductor with a 5 cm long silk thread inside the endoprosthesis. The pump works simulating the regular heart rhythm or premature ventricular contractions. We observed an intense pressure effect of the first post-extrasystolic wave on the rotameter tube, with the formation of reflected, standing waves (the pressure increased by 160% compared with the regular heart rhythm). Conclusion. With the spread of the first post-extrasystolic wave, a “hydraulic shock” occurs in the arterial vessel. Its mechanical effect can be the starting point for the onset and progression of restenosis in an implanted intravascular stent.