Cassava is grown because of its starchy roots, but the leaves being rich in protein are mostly underutilized. For protein recovery, mechanical juice extraction from cassava leaves and the extraction process was evaluated using computational fluid dynamics (CFD) simulation. The influence of input variables such as nozzle diameter and rotational speed of the screw was investigated in relation to process efficiency. The highest green juice extraction yield (81.0%) from cassava leaves and dry matter of press cake (61.3%) were achieved by using 4 mm nozzle diameter and 18 rpm screw speed. The protein content of the cassava leaves, press cake, juice sediment, and juice supernatant was found to be 31.5%, 27.7%, 26.2%, and 12.4%, respectively. The crude protein, cellulose, hemicellulose, lignin, and total phenolic content mainly accumulated in the press cake. The screw pressing concentrated the amino acids in the press cake and the juice sediment.