This study addresses issues which arise in the computational and experimental modelling of flow and heat / mass transfer in membrane distillation and other processes adopting spacer-filled channels the combined effects of the main parameters that characterize the process (notably spacer pitch to channel height ratio l/H, flow attack angle γ and Reynolds number Re) and the applicability of simple correlations; the influence of the spacer's thermal conductivity. In regard to the complex influence of the parameters, Re, l/H and γ were found to interact heavily, making a separate-effect analysis impossible and power-law friction or heat / mass transfer correlations of little use. Thermal conduction in the spacer, even for low-conductivity polymeric spacers (λ≈0.15 Wm -1 K -1 ), was found to be responsible for up to 10% of the total heat transfer;