Modeling of the Acoustic Field Produced by Diagnostic Ultrasound Arrays in Plane and Diverging Wave Modes

Lai, Ting-Yu; Bruce, Matthew; Averkiou, Michalakis A.

doi:10.1109/tuffc.2019.2908831

Cited by 10 publications

(7 citation statements)

References 35 publications

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“…At 8 mm the acoustic pressure is about 20% lower and at 28 mm the pressure is about 30% lower. The highest region of pressure is not at the centre but at the probe edge where side lobes are generated and about 20% higher than at the elevational focus in the centre [57]. This is true at zero degree transmission but changes when transmitting with a tilted angle.…”

Section: Discussionmentioning

confidence: 87%

Fast and Selective Super-Resolution Ultrasound In Vivo With Acoustically Activated Nanodroplets

Riemer

Toulemonde

Yan

et al. 2023

IEEE Trans. Med. Imaging

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Perfusion by the microcirculation is key to the development, maintenance and pathology of tissue. Its measurement with high spatiotemporal resolution is consequently valuable but remains a challenge in deep tissue. Ultrasound Localization Microscopy (ULM) provides very high spatiotemporal resolution but the use of microbubbles requires low contrast agent concentrations, a long acquisition time, and gives little control over the spatial and temporal distribution of the microbubbles. The present study is the first to demonstrate Acoustic Wave Sparsely-Activated Localization Microscopy (AWSALM) and fast-AWSALM for in vivo super-resolution ultrasound imaging, offering contrast on demand and vascular selectivity. Three different formulations of acoustically activatable contrast agents were used. We demonstrate their use with ultrasound mechanical indices well within recommended safety limits to enable fast on-demand sparse activation and destruction at very high agent concentrations. We produce super-localization maps of the rabbit renal vasculature with acquisition times between 5.5 s and 0.25 s, and a 4-fold improvement in spatial resolution. We present the unique selectivity of AWSALM in visualizing specific vascular branches and downstream microvasculature, and we show super-localized kidney structures in systole (0.25 s) and diastole (0.25 s) with fast-AWSALM outdoing microbubble based ULM. In conclusion, we demonstrate the feasibility of fast and selective measurement of microvascular dynamics in vivo with subwavelength resolution using ultrasound and acoustically activatable nanodroplet contrast agents.

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Section: Discussionmentioning

confidence: 87%

Fast and Selective Super-Resolution Ultrasound In Vivo With Acoustically Activated Nanodroplets

Riemer

Toulemonde

Yan

et al. 2023

IEEE Trans. Med. Imaging

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“…As mentioned in Section 2.3.2 , the attenuation in water is usually described by a quadratic dependence on the frequency. The attenuation coefficients vary in a wide range between

[ 37 , 39 , 40 , 41 ] and 1

[ 43 , 44 ] and up to 44

[ 36 ].…”

Section: Results and Discussionmentioning

confidence: 99%

“…The literature typically describes the frequency-dependent attenuation

by a power law [ 35 , 36 ]. For water, a quadratic dependence on frequency is commonly assumed [ 35 , 37 , 38 , 39 , 40 , 41 , 42 ].

…”

Section: Materials and Methodsmentioning

confidence: 99%

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Frequency-Resolved High-Frequency Broadband Measurement of Acoustic Longitudinal Waves by Laser-Based Excitation and Detection

Brand,

Drese

2024

Sensors

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Optoacoustics is a metrology widely used for material characterisation. In this study, a measurement setup for the selective determination of the frequency-resolved phase velocities and attenuations of longitudinal waves over a wide frequency range (3– 55MHz) is presented. The ultrasonic waves in this setup were excited by a pulsed laser within an absorption layer in the thermoelastic regime and directed through a layer of water onto a sample. The acoustic waves were detected using a self-built adaptive interferometer with a photorefractive crystal. The instrument transmits compression waves only, is low-contact, non-destructive, and has a sample-independent excitation. The limitations of the approach were studied both by simulation and experiments to determine how the frequency range and precision can be improved. It was shown that measurements are possible for all investigated materials (silicon, silicone, aluminium, and water) and that the relative error for the phase velocity is less than 0.2 .

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“…Although multiple ultrasound research platforms support plane-wave acquisitions, a limited number of commercial ultrasound system architectures support plane-wave acquisitions, and to date, major ultrasound manufacturers have yet to release a plane-wave microbubble imaging mode. An additional challenge faced by plane wave-based approaches using 1-D arrays is the fixed elevational focus, which limits the penetration of unfocused beams (Lai et al 2019).…”

Section: Practical Requirements For Multipulse Schemesmentioning

confidence: 99%

Imaging Methods for Ultrasound Contrast Agents

Averkiou

Bruce

Powers

et al. 2020

Ultrasound in Medicine & Biology

Self Cite

122

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Microbubble contrast agents were introduced more than 25 years ago with the objective of enhancing blood echoes and enabling diagnostic ultrasound to image the microcirculation. Cardiology and oncology waited anxiously for the fulfillment of that objective with one clinical application each: myocardial perfusion, tumor perfusion and angiogenesis imaging. What was necessary though at first was the scientific understanding of microbubble behavior in vivo and the development of imaging technology to deliver the original objective. And indeed, for more than 25 years bubble science and imaging technology have evolved methodically to deliver contrast-enhanced ultrasound. Realization of the basic bubbles properties, non-linear response and ultrasound-induced destruction, has led to a plethora of methods; algorithms and techniques for contrast-enhanced ultrasound (CEUS) and imaging modes such as harmonic imaging, harmonic power Doppler, pulse inversion, amplitude modulation, maximum intensity projection and many others were invented, developed and validated. Today, CEUS is used everywhere in the world with clinical indications both in cardiology and in radiology, and it continues to mature and evolve and has become a basic clinical tool that transforms diagnostic ultrasound into a functional imaging modality. In this review article, we present and explain in detail bubble imaging methods and associated artifacts, perfusion quantification approaches, and implementation considerations and regulatory aspects.

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Modeling of the Acoustic Field Produced by Diagnostic Ultrasound Arrays in Plane and Diverging Wave Modes

Cited by 10 publications

References 35 publications

Fast and Selective Super-Resolution Ultrasound In Vivo With Acoustically Activated Nanodroplets

Fast and Selective Super-Resolution Ultrasound In Vivo With Acoustically Activated Nanodroplets

Frequency-Resolved High-Frequency Broadband Measurement of Acoustic Longitudinal Waves by Laser-Based Excitation and Detection

Imaging Methods for Ultrasound Contrast Agents

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