Models are proposed for the thinning of an interphase film in petroleum emulsion separation processes, taking account of the Marangoni effect and the asphaltene content. The thickness of the adsorption layer on the surface of a drop is estimated. The computational and experimental data on the time dependencies of the interphase film thickness are compared.Petroleum emulsion separation processes are a critical step in the preparation of petroleum crude for refining. A significant number of studies [1-4] are devoted to theoretical and experimental investigations of the mechanism responsible for the formation, stabilization, and breakdown of petroleum emulsions as heterogeneous systems. Many problems associated with phenomena occurring on the petroleum-water interface, coalescence and break-up of water drops, and stratification and precipitation, however, have yet to be resolved. Petroleum emulsions are polydisperse systems with water drops ranging in size from 1 to 150 μm, and contain coarsely disperse (150-1,000 μm) and finely disperse (0.001-1 μm) particles. Such a scatter of particle sizes exerts a major influence on the mechanism for breakdown, separation, and precipitation of the drops in petroleum emulsions, which can be divided into the following stages.1.Deformation and breakdown of adsorption layers on the petroleum-water interface within the volume of the emulsion using surface-active substances (SAS) at certain temperatures (60-70°C) and pressures. 2. Convergence and collision of drops of various size with the formation an interface film. It should be pointed out that transport of drops in a polydisperse system is determined primarily by the hydrodynamic conditions and turbulence of the flow. In [5][6][7], it is demonstrated that under isotropic turbulence, the frequency of collisions between drops is proportional to ( ) 3 1 2 /