Modeling of the growth hormone secretagogue receptor antagonistic activity using chemometric tools

Sharma, S. K.; Sharma, B. K.; Pilania, Pradeep; Singh, Prithvi; Prabhakar, Yenamandra S.

doi:10.1080/14756360802608054

Cited by 5 publications

(2 citation statements)

References 33 publications

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“…Its procedural aspects and implementation are discussed in some of our recent publications [51][52][53][54][55]. It involves selected subset regressions.…”

Section: Model Developmentmentioning

confidence: 99%

QSAR rationales for the 1,2-diarylcyclopentenes as prostaglandin EP1 receptor antagonists: Potentially useful in the treatment of inflammatory pain

Sharma¹,

Pilania²,

Singh³

2010

Eur. J. Chem.

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“…Its procedural aspects and implementation are discussed in some of our recent publications [51][52][53][54][55]. It involves selected subset regressions.…”

Section: Model Developmentmentioning

confidence: 99%

QSAR rationales for the 1,2-diarylcyclopentenes as prostaglandin EP1 receptor antagonists: Potentially useful in the treatment of inflammatory pain

Sharma¹,

Pilania²,

Singh³

2010

Eur. J. Chem.

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“…Its procedural aspects and implementations are discussed in our publications [35][36][37][38][39][40] . It involves selected subset regressions.…”

Section: Model Developmentmentioning

confidence: 99%

Cp-MLR Directed Qsar Rationales for the Activity Profile of (Phenylpiperazinyl-Alkyl) Oxindoles as 5-Ht7 Receptor Ligands

Choudhary¹,

Sharma²

2015

Int. J. Res. Ayurveda Pharm.

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The 5-HT7 receptor binding affinities of the oxindole derivatives have been quantitatively analyzed in terms of Dragon descriptors. The derived QSAR models have provided rationales to explain the binding affinity of titled compounds. In order to improve the 5-HT7 receptor binding affinity of a compound higher value of molecular topology and symmetry accounting parameter path/walk 2-Randic shape index (descriptor PW2) and lower value of eigenvector coefficient sum from adjacency matrix (descriptor VEA1) are favorable. Presence of more number of sp 3 hybridized secondary carbon atoms (descriptor nCs) and secondary aliphatic amides (descriptor nCONHR) in a molecule will be supportive to the activity. The associations of masses to the eigenvalue n.4 of Burden matrix (BEHm4), van der Waals volume to path length 2 of Geary autocorrelation (GATS2v) and Sanderson electronegativity to path length 6 of Moran autocorrelation (MATS6e) and path length 4 of Geary autocorrelation (GATS4e) have shown the prevalence of atomic properties and charge content in terms of 9 th and 5 th order topological and mean topological charge indices (GGI9 and JGI5) to explain the binding affinity. The PLS analysis has also confirmed the dominance of information content of the CP-MLR identified descriptors. The derived models and participating descriptors in them have suggested that the substituents of oxindole moiety have sufficient scope for further modification.

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Review of Novel Aspects of the Regulation of Ghrelin Secretion

Massadi¹,

Lear²,

Müller³

et al. 2014

CDM

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The role of ghrelin in regulating metabolism and energy balance has been a subject of intense focus ever since its discovery. Ghrelin regulates energy balance in the short term by induction of appetite and in the longer term by increasing body weight and adiposity. It is the only known peripheral orexigenic hormone and one of the most potent endogenous orexigenic factors discovered to date. However, whilst extensively studied, the mechanism of ghrelin secretion is not well understood. A better understanding of the pathways controlling ghrelin secretion could be useful in the development of new therapeutic approaches to appetite-related disorders. Here, we discuss current knowledge of the processes that control ghrelin secretion, focusing on neural, chemical and hormonal stimuli. In addition, we share our view on the potential of targeting ghrelin for the treatment of eating disorders such as obesity, anorexia nervosa and cachexia.

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Modeling of the growth hormone secretagogue receptor antagonistic activity using chemometric tools

Cited by 5 publications

References 33 publications

QSAR rationales for the 1,2-diarylcyclopentenes as prostaglandin EP1 receptor antagonists: Potentially useful in the treatment of inflammatory pain

QSAR rationales for the 1,2-diarylcyclopentenes as prostaglandin EP1 receptor antagonists: Potentially useful in the treatment of inflammatory pain

Cp-MLR Directed Qsar Rationales for the Activity Profile of (Phenylpiperazinyl-Alkyl) Oxindoles as 5-Ht7 Receptor Ligands

Review of Novel Aspects of the Regulation of Ghrelin Secretion

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