Modeling of the<i>in vivo</i>kinetics of antioxidants delineates suitable parameters for selecting potential antioxidant adjuvants for cancer therapy

Yang, Ming; Chuang, Chao Ming; Hsieh, Chiu Lan; Wang, Hui Er; Chen, Kuan Chou; Chiu, Wen Ta; Shih, Chün Ming; Peng, Robert Y.

doi:10.3109/13880200903127375

Cited by 1 publication

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“…This singlet oxygen is a highly reactive species which gives the photo oxygenation reaction. Methylene blue is reportedly efficient sensitizers for the conversion of triplet oxygen to singlet oxygen in the presence of light [15][16][17][18][19] . The first-order kinetic constant was calculated for the exposed solutions of the different concentration of the substrate [2TBA] and the sensitizer MB in the aerobic as well as in the anaerobic condition.…”

Section: Effect Of the Anaerobic Conditionmentioning

confidence: 99%

Photoinduced Electron Transfer Reaction of 2-Thiobarbituric Acid and Methylene Blue: Mechanism and Kinetics

2013

Chem Sci Trans

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Abstract:Barbiturates are known to have hypnotic properties and are used as active moiety on central nervous system. Depends up on the experiments conditions and functional group present on the drugs, make the drugs labile to photodecomposition. The photosensitized reaction of 2-thiobarbituric acid (2TBA) with methylene blue (MB) in alkaline medium using visible light has been studied. 2TBA exists in protonated and deprotonated form in equilibrium in alkaline medium. Photosensitized electron transfer from the deprotonated 2TBA to excited state MB takes place and the energy is transferred to 2TBA molecule which undergoes chemical reaction. The interconversion of protonated form to deprotonated form during the reaction is observed. The rate of the reaction has been calculated and the effect of pH, concentration of the sensitizer, the light intensity on the rate of the reaction has been studied. The quantum efficiency of the photo chemical reaction is calculated using potassium ferrioxalate actinometer and the effect of the concentration of the substrate on the quantum efficiency is calculated. The reaction mechanism and the excited states involved have been suggested.

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Section: Effect Of the Anaerobic Conditionmentioning

confidence: 99%

Photoinduced Electron Transfer Reaction of 2-Thiobarbituric Acid and Methylene Blue: Mechanism and Kinetics

2013

Chem Sci Trans

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Modeling of thein vivokinetics of antioxidants delineates suitable parameters for selecting potential antioxidant adjuvants for cancer therapy

Abstract: (2010) Modeling of the invivo kinetics of antioxidants delineates suitable parameters for selecting potential antioxidant adjuvants for cancer therapy, Pharmaceutical Biology, 48:3, 306-317,

Cited by 1 publication

References 44 publications

Photoinduced Electron Transfer Reaction of 2-Thiobarbituric Acid and Methylene Blue: Mechanism and Kinetics

Photoinduced Electron Transfer Reaction of 2-Thiobarbituric Acid and Methylene Blue: Mechanism and Kinetics

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