Modeling Processes of Storage of Platelet-Containing Transfusion Media in Polymer Containers

Гудков, А. Г.; Bobrikhin, A. F.; Zelenov, M. S.; Leushin, V. Yu.; Lemondzhava, V. N.; Marzhanovsky, I. N.; Chernyshev, A. V.

doi:10.1007/s10527-016-9622-2

Cited by 13 publications

(2 citation statements)

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“…Моделирование процесса перемешивания образца плазмы крови в жидком состоянии в герметичном полимерном контейнере под действием на него термических и механических воздействий может быть третьей самостоятельной задачей. Подобная задача была решена для процесса хранения при заданной положительной температуре для полимерных контейнеров с трансфузионными средами, содержащими тромбоциты [86][87][88]. Дополнительным подтверждением сложности задачи численного моделирования динамических процессов замораживания и размораживания плазмы крови является невозможность ее решения стандартными средствами таких программных обеспечений, как: ANSYS CFX, ANSYS Fluent, COMSOL Multiphysics, FLOW-3D, а также OpenFOAM.…”

Section: наименование вида информационных сведений об экспериментахunclassified

Thermolability of factor VIII in donor fresh frozen blood plasma

Lemondzhava

Чечеткин

Гудков

et al. 2021

Gematologiâ i transfuziologiâ

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A criterion of the quality of fresh frozen blood plasma (FFP) is the activity of clotting factor VIII (FVIII).Aim — to identify technological barriers in the study of FVIII thermolability and to describe the requirements for experiments, providing new knowledge about the thermolability of this factor.Basic information. An analysis of domestic and foreign publications devoted to the study of the mechanisms responsible for reducing the value of FVIII activity in donor blood plasma from the moment of donation to the moment of transfusion was carried out. Data on the decrease in FVIII activity at various stages of work with blood plasma are presented. An analysis of methods for preparing samples for studying changes in the values of FVIII in donor blood plasma was performed. The existence of contradictory conclusions about the infl uence on the change in FVIII at the thawing stage of various values of the effects on FFP and poor knowledge of the change in the indicator at the stage of heating to the transfusion temperature after the end of the phase transition in the samples was established. The fundamental differences in the methods of preparing and conducting experiments in previous works are determined. Methods for increasing the reliability of experimental results for studying the thermal lability of FVIII are proposed.

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Section: наименование вида информационных сведений об экспериментахunclassified

Thermolability of factor VIII in donor fresh frozen blood plasma

Lemondzhava

Чечеткин

Гудков

et al. 2021

Gematologiâ i transfuziologiâ

Self Cite

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“…Thus, the creation of a system capable of creating and maintaining the required differential pressure to ensure blood circulation is a relevant problem. For determination of the required parameters of a vacuum system that provides specified characteristics, development of a calculation method is required [3,4]. The developed method is considered in the context of the blood transportation process by heart.…”

Section: Introductionmentioning

confidence: 99%

Development of calculation method of main parameters of vacuum liquid transportation system

Demikhov

Ochkov

Gordeeva

2018

IOP Conf. Ser.: Mater. Sci. Eng.

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View the article online for updates and enhancements. Related contentVacuum pumping system for the multiaperture low-energy continuously-operated electron accelerator with a high-density beam current A G Ivanov, D A Karpov, S L Kosogorov et al. Abstract. The design of a vacuum pumping system based on the principle of the displacement membrane was proposed. This principle does not imply contact of the working metal surfaces with the transported liquid. This article presents a calculation method of the main parameters of the proposed vacuum fluid transportation system. As a result of the calculation, the values of the pumping speed, the dimensions of the displacement membrane, the required chamber height, the pressure drop in the chamber, required to ensure the deflection of the displacement membrane, were obtained. Based on the proposed method, a program for calculation the main parameters of a liquid transfer system based on the mathematical software MathCAD was developed.

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