Modeling Risk Factors and Confounding Effects in Stroke

McColl, Barry W.; Howells, David W.; Rothwell, Nancy J.

doi:10.1007/978-1-4939-5620-3_9

Cited by 2 publications

(2 citation statements)

References 205 publications

(116 reference statements)

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“…In spite of disagreements on the effects of aging on infarct volume, invariably significantly higher mortality rates and more severe neurological impairments are found in older animals, consistent with clinical data. [74][75][76][77][78] Such detrimental effects, in terms of function and animal welfare, are a direct consequence of the ageing process per se rather than the amount of ischemic damage generated. If the infarct volume is reduced in aged females to that seen in young females by hormone supplementation, the poorer functional ability and increased mortality remain in the aged females.…”

Section: Specific Requirements For Aged Animals and Those With Co-morbiditiesmentioning

confidence: 99%

The IMPROVE Guidelines (Ischaemia Models: Procedural Refinements Of in Vivo Experiments)

Sert

Alfieri

Allan

et al. 2017

J Cereb Blood Flow Metab

134

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Most in vivo models of ischaemic stroke target the middle cerebral artery and a spectrum of stroke severities, from mild to substantial, can be achieved. This review describes opportunities to improve the in vivo modelling of ischaemic stroke and animal welfare. It provides a number of recommendations to minimise the level of severity in the most common rodent models of middle cerebral artery occlusion, while sustaining or improving the scientific outcomes. The recommendations cover basic requirements pre-surgery, selecting the most appropriate anaesthetic and analgesic regimen, as well as intraoperative and post-operative care. The aim is to provide support for researchers and animal care staff to refine their procedures and practices, and implement small incremental changes to improve the welfare of the animals used and to answer the scientific question under investigation. All recommendations are recapitulated in a summary poster (see supplementary information).

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Section: Specific Requirements For Aged Animals and Those With Co-morbiditiesmentioning

confidence: 99%

The IMPROVE Guidelines (Ischaemia Models: Procedural Refinements Of in Vivo Experiments)

Sert

Alfieri

Allan

et al. 2017

J Cereb Blood Flow Metab

134

View full text Add to dashboard Cite

show abstract

“…Furthermore, some facets of ischemic stroke are not feasible in animal models, including preventative strategies ( 56 ). Although comorbidities such as diabetes and hypertension can be induced into the rodents being tested, the cost is high ( 58 ). Thus, most mice being tested are young and healthy males, although female mice account for a majority of stroke mortalities ( 59 ).…”

Section: Methodsmentioning

confidence: 99%

Neuroprotection in Acute Ischemic Stroke: A Battle Against the Biology of Nature

et al. 2022

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Stroke is the second most common cause of global death following coronary artery disease. Time is crucial in managing stroke to reduce the rapidly progressing insult of the ischemic penumbra and the serious neurologic deficits that might follow it. Strokes are mainly either hemorrhagic or ischemic, with ischemic being the most common of all types of strokes. Thrombolytic therapy with recombinant tissue plasminogen activator and endovascular thrombectomy are the main types of management of acute ischemic stroke (AIS). In addition, there is a vital need for neuroprotection in the setting of AIS. Neuroprotective agents are important to investigate as they may reduce mortality, lessen disability, and improve quality of life after AIS. In our review, we will discuss the main types of management and the different modalities of neuroprotection, their mechanisms of action, and evidence of their effectiveness after ischemic stroke.

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Modeling Risk Factors and Confounding Effects in Stroke

Cited by 2 publications

References 205 publications

The IMPROVE Guidelines (Ischaemia Models: Procedural Refinements Of in Vivo Experiments)

The IMPROVE Guidelines (Ischaemia Models: Procedural Refinements Of in Vivo Experiments)

Neuroprotection in Acute Ischemic Stroke: A Battle Against the Biology of Nature

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