Modeling Tardive Dyskinesia: Predictive 5-HT2C Receptor Antagonist Treatment

Contribution of Decreased Serotonin Release to the Antidyskinetic Effects of Deep Brain Stimulation in a Rodent Model of Tardive Dyskinesia: Comparison of the Subthalamic and Entopeduncular Nuclei

“…Moreover, SSRI treatment has been shown to exacerbate or precipitate TD in patients concomitantly administered antipsychotics. In clinical and preclinical studies, 5-HT receptor antagonism can reduce VCMs (Kostrzewa et al, 2007;Creed-Carson et al, 2011). To determine whether reduced 5-HT activity is sufficient to suppress HAL-induced VCMs, we administered the 5-HT 1A inhibitory autoreceptor agonist, 8-OH-DPAT.…”

“…5-HT provides extensive innervation to the basal ganglia where it mod-ulates dopamine neurotransmission (Alex and Pehek, 2007;Di Matteo et al, 2008). The lower incidence of TD associated with atypical antipsychotics has been ascribed to their 5-HT 2 receptor antagonism (Meltzer and Nash, 1991;Kapur et al, 1999;Stahl, 1999), while antagonism of 5-HT 2C receptors suppresses VCMs in rats (Kostrzewa et al, 2007;Creed-Carson et al, 2011). Moreover, symptoms of TD can be exacerbated by concomitant treatment with selective serotonin reuptake inhibitors (SSRIs), which increase synaptic 5-HT levels (Ketai, 1993;D'Souza et al, 1994;Dubovsky and Thomas, 1996;Sandler, 1996;Lauterbach and Shillcutt, 1997;Caley, 1998).…”

Antiparkinsonian Treatment for Depression in Parkinson's Disease: Are Selective Serotonin Reuptake Inhibitors Recommended?

“…Agomelatin stimulates melatoninergic receptors and blocks central 5-HT 2C receptors [140,141] . Blockade of 5-HT 2C receptors may have many benefits in the context of PD, such as improvements in motor function and mood disorders, although the full picture is unclear [142][143][144] . Drugs such as agomelatin should be tested and their effects should be compared to those of drugs targeting transporters.…”

Treatment of Tardive Dyskinesia with Aripiprazole

“…Apparently, there is an optimal range for coordinate block of dopamine D2 receptors with 5-HT2 receptors, since some of the classical antipsychotics also block both receptors but still produce TD, and 5-HT2 receptor antagonists are effective in rodent models of TD (Kostrzewa et al 2007). Furthermore, there is some evidence that these second generation antipsychotics may have a therapeutic effect on TD (Margolese et al 2005).…”