Modeling the acoustic radiation force in microfluidic chambers

Fisher, Karl A.; Miles, Robin R.

doi:10.1121/1.2839140

Cited by 17 publications

(8 citation statements)

References 8 publications

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“…3). Fisher's combined P analyses (Fisher and Miles 2008), which combined the P values from association tests in the study populations, showed that rs10816533 has more strong association signal ( P = 1.55 × 10 −6 ).…”

Section: Replication Studymentioning

confidence: 99%

Genome-wide association scan for stature in Chinese: evidence for ethnic specific loci

et al. 2008

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In Caucasian, several studies have identified some common variants associated with human stature variation. However, no such study was performed in Chinese, which is the largest population in the world and evidently differs from Caucasian in genetic background. To identify common or ethnic specific genes for stature in Chinese, an initial GWAS and follow-up replication study were performed. Our initial GWAS study found that a group of 13 contiguous SNPs, which span a region of ∼150 kb containing two neighboring genes, zinc finger protein (ZNP) 510 and ZNP782, achieved strong signals for association with stature, with P values ranging from 9.71 × 10 −5 to 3.11 × 10 −6 . After false discovery rate correction for multiple testing, 9 of the 13 SNPs remain significant (FDR q = 0.036-0.046). The follow-up replication study in an independent 2,953 unrelated southern NIH-PA Author ManuscriptNIH-PA Author Manuscript NIH-PA Author ManuscriptChinese confirmed the association of rs10816533 with stature (P = 0.029). All the13 SNPs were in consistently strong linkage disequilibrium (D′ > 0.99) and formed a single perfect haplotype block. The minor allele frequencies for the 13 contiguous SNPs have evidently ethnic difference, which range from 0.21 to 0.33 in Chinese but have as low as ∼0.017 reported in dbSNP database in Caucasian. The present results suggest that the genomic region containing the ZNP510 and ZNP782 genes is an ethnic specific locus associated with stature variation in Chinese.

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Section: Replication Studymentioning

confidence: 99%

Genome-wide association scan for stature in Chinese: evidence for ethnic specific loci

et al. 2008

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“…Due to AF of CNP11164 (AF = 0.0031) and CNP10799 (AF = 0.003) is smaller than 1%, only CNP182 and CNP267 were analyzed for replicate association and reached p values at 2.39E-01 and 5.66E-03, respectively (Table 2). Meta-analysis (Fisher's combined p method [25]) was used to combine association tests in the two populations. The Fisher's combined p value (p = 3.09E-04) for CNP267 is nearly approaching the significant level after multiple testing (0.05/194 = 2.58E-04).…”

Section: Resultsmentioning

confidence: 99%

Copy Number Variation in CNP267 Region May Be Associated with Hip Bone Size

et al. 2011

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Osteoporotic hip fracture (HF) is a serious global public health problem associated with high morbidity and mortality. Hip bone size (BS) has been identified as one of key measurable risk factors for HF, independent of bone mineral density (BMD). Hip BS is highly genetically determined, but genetic factors underlying BS variation are still poorly defined. Here, we performed an initial genome-wide copy number variation (CNV) association analysis for hip BS in 1,627 Chinese Han subjects using Affymetrix GeneChip Human Mapping SNP 6.0 Array and a follow-up replicate study in 2,286 unrelated US Caucasians sample. We found that a copy number polymorphism (CNP267) located at chromosome 2q12.2 was significantly associated with hip BS in both initial Chinese and replicate Caucasian samples with p values of 4.73E-03 and 5.66E-03, respectively. An important candidate gene, four and a half LIM domains 2 (FHL2), was detected at the downstream of CNP267, which plays important roles in bone metabolism by binding to several bone formation regulator, such as insulin-like growth factor-binding protein 5 (IGFBP-5) and androgen receptor (AR). Our findings suggest that CNP267 region may be associated with hip BS which might influence the FHL2 gene downstream.

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“…To correct for the effect of potential population stratification, we conducted a principal component analysis on genome-wide SNP data with EIGENSTRAT [29] and included the top ten principal components as covariates. Fisher’s method [30] was used to combine the p -values from the discovery sample and replication sample.…”

Section: Methodsmentioning

confidence: 99%

Genome-Wide Association Study Identified Copy Number Variants Important for Appendicular Lean Mass

et al. 2014

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Skeletal muscle is a major component of the human body. Age-related loss of muscle mass and function contributes to some public health problems such as sarcopenia and osteoporosis. Skeletal muscle, mainly composed of appendicular lean mass (ALM), is a heritable trait. Copy number variation (CNV) is a common type of human genome variant which may play an important role in the etiology of many human diseases. In this study, we performed genome-wide association analyses of CNV for ALM in 2,286 Caucasian subjects. We then replicated the major findings in 1,627 Chinese subjects. Two CNVs, CNV1191 and CNV2580, were detected to be associated with ALM (p = 2.26×10−2 and 3.34×10−3, respectively). In the Chinese replication sample, the two CNVs achieved p-values of 3.26×10−2 and 0.107, respectively. CNV1191 covers a gene, GTPase of the immunity-associated protein family (GIMAP1), which is important for skeletal muscle cell survival/death in humans. CNV2580 is located in the Serine hydrolase-like protein (SERHL) gene, which plays an important role in normal peroxisome function and skeletal muscle growth in response to mechanical stimuli. In summary, our study suggested two novel CNVs and the related genes that may contribute to variation in ALM.

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Modeling the acoustic radiation force in microfluidic chambers

Cited by 17 publications

References 8 publications

Genome-wide association scan for stature in Chinese: evidence for ethnic specific loci

Genome-wide association scan for stature in Chinese: evidence for ethnic specific loci

Copy Number Variation in CNP267 Region May Be Associated with Hip Bone Size

Genome-Wide Association Study Identified Copy Number Variants Important for Appendicular Lean Mass

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