Modeling the coating layer thickness in a pharmaceutical coating process

Madlmeir, Stefan; Forgber, Thomas; Trogrlic, M.; Jajčević, Dalibor; Kape, A.; Contreras, L.; Carmody, Alan; Liu, Peiyuan; Davies, C.; Sarkar, Avik; Khinast, Johannes

doi:10.1016/j.ejps.2021.105770

Cited by 19 publications

(6 citation statements)

References 50 publications

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Section: Resultsmentioning

confidence: 99%

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Evaluation of Coating Variability in a Wurster Coater via Ray Tracing and Spray Zone Methods

Song,

Zhou,

Bai

et al. 2024

Ind. Eng. Chem. Res.

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This study investigated systematically the coating processes of ellipsoidal tablets in a Wurster coater by coupling CFD-DEM simulations and postprocesses. The tablets were represented by superquadrics in the CFD-DEM simulations. Two postprocessing methods (i.e., the ray tracing method (RTM) and the spray zone method (SZM)) were established and compared. Their algorithms were introduced in detail, and the effects of important model and operation parameters were analyzed, including the number of rays, the number of facets per tablet, the time step of the postprocesses, the fluidizing gas velocity, and the spray angle. Implemented in a postprocessing mode, the two methods provided a flexibility to simulate different spray settings with only one round of DEM runs. The RTM is able to provide multiple pieces of information relating to the coating processes but with a relatively high computation cost. By contrast, the SZM is simpler and faster but cannot estimate the intratablet coating variability and the coating efficiency. Besides, it is generally difficult to define a spray zone accurately under various conditions for this method. There is no obviously better choice at this stage, and more comparisons with experiments should be implemented in the future.

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Section: Resultsmentioning

confidence: 99%

“…Madlmeir et al 52 studied a Wurster coating process using CFD-DEM and Monte Carlo approaches and found the two methods were able to providing quantitatively agreeing results. The calculated CMD curves in Figure 12(b) both exhibited a similar monopeaked shape (centered at ∼0.3 μg) as in Figure 12(a).…”

Section: Number Of Raysmentioning

confidence: 99%

Evaluation of Coating Variability in a Wurster Coater via Ray Tracing and Spray Zone Methods

Song,

Zhou,

Bai

et al. 2024

Ind. Eng. Chem. Res.

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“…Representative unresolved problems in fluidized bed granulation/coating include gas-solid hydrodynamics under special conditions (such as fine or cohesive powders), heat and mass transfer (temperature and moisture distribution), liquid bridge force modeling, and microscopic particle growth mechanisms. Many researchers have attempted to unravel the veil of granulation and coating processes using analytical methods [4][5][6][7], experimental methods [8][9][10][11][12][13][14][15][16][17][18][19], numerical simulation [20][21][22][23][24][25][26][27][28][29][30][31][32][33], or a combination of experimental and numerical methods [34][35][36][37][38][39][40][41][42][43][44][45]. At the early stage, experimental research was largely conducted on a macro/global scale and confined to a specific apparatus (see Figure 1).…”

Section: Introductionmentioning

confidence: 99%

Review of CFD-DEM Modeling of Wet Fluidized Bed Granulation and Coating Processes

et al. 2023

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Wet fluidized bed granulation and coating processes have been widely used in the pharmaceutical and food industries. The complex gas–solid flow coupled with heat and mass transfer in such processes made it hard to form complete control over the apparatuses. To serve better design, scaling-up, and optimization of granulators and coaters, the underlying micro-scale mechanisms must be clarified. Computational fluid dynamics coupled with the discrete element method (CFD-DEM) provides a useful tool to study in-depth the gas-solid hydrodynamics of the granulation and coating processes. This review firstly introduced the fundamental theory of CFD-DEM from governing equations, force calculation, and coupling schemes. Then the application of CFD-DEM in simulating wet fluidized bed granulation and coating was presented. Specifically, the research focus and the role of CFD-DEM in resolving issues were discussed. Finally, the outlook on the development of CFD-DEM in the context of granulation and coating was given.

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“…The trend of research developments on mobile hybrid systems continues to increase [11]. By paying attention to the facts about the development of current research trends that lead to the development of a mobile hybrid system, research on medicine distribution through an information system based on a mobile hybrid system [12], which was developed with scientific principles using the rule based reasoning method by involving experts in the pharmaceutical field is part of steps to ensure the availability of medicines effectively and efficiently in accordance with the basic principles of the rules of the supply chain information system [13]. The development of mobile hybrid system technology in this new framework system model can make transactions and medicine distribution supervision done online and real time [14].…”

Section: Introductionmentioning

confidence: 99%

The new model for medicine distribution by combining of supply chain and expert system using rule-based reasoning method

Mufadhol

Mustafid²,

Jie³

et al. 2023

IJ-AI

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The medicine distribution supply chain is important, especially during the COVID-19 pandemic, because delays in medicine distribution can increase the risk for patients. So far, the distribution of medicines has been carried out exclusively and even some medicines are distributed on a limited basis because they require strict supervision from the Medicine Supervisory Agency in each department. However, the distribution of this medicine has a weakness if at one public Health center there is a shortage of certain types of medicines, it cannot ask directly to other public Health center, thus allowing the availability of medicines not to be fulfilled. An integrated process is needed that can accommodate regulations and leadership policies and can be used for logistics management that will be used in medicine distribution. This study will create a new model by combining supply chains with information systems and expert systems using the rule-based reasoning method as an inference engine that can be developed for medicine distribution based on a mobile hybrid system in the Demak District Health Office, Indonesia. So that a new framework model based on a mobile hybrid system can facilitate the distribution of medicines effectively and efficiently.

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Modeling the coating layer thickness in a pharmaceutical coating process

Cited by 19 publications

References 50 publications

Evaluation of Coating Variability in a Wurster Coater via Ray Tracing and Spray Zone Methods

Evaluation of Coating Variability in a Wurster Coater via Ray Tracing and Spray Zone Methods

Review of CFD-DEM Modeling of Wet Fluidized Bed Granulation and Coating Processes

The new model for medicine distribution by combining of supply chain and expert system using rule-based reasoning method

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