Modeling the contractile characteristics of smooth muscle from the porcine small intestine

Kim, Hunhee; Suh, Jungjoon; Lee, Young-Ho; Lee, Tae-Kyeong; Hong, Junghwa

doi:10.1080/19768354.2015.1057614

Cited by 2 publications

(1 citation statement)

References 16 publications

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“…Using the mechanical test mentioned above, the force development under different stimulation degrees associated with specific KCl concentrations has been reported, suggesting that calponin plays a fundamental role in controlling the SMC contraction. (Kim et al, 2015). described the passive and active mechanical behavior of the porcine small intestine, performing tensile tests to obtain the passive response, along with isometric and isotonic experiments to capture the active response, determining maximum loads and stresses in the tensile test and isometric experiment and maximum velocity muscular contraction from the isotonic experiment.…”

Section: Open Access Edited Bymentioning

confidence: 99%

Characterization of the active response of a guinea pig carotid artery

Navarrete

Varela

López

et al. 2022

Front. Bioeng. Biotechnol.

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This work presents a characterization of the active response of the carotid artery of guinea pig fetuses through a methodology that encompasses experiments, modeling and numerical simulation. To this end, the isometric contraction test is carried out in ring samples subjected to different levels of KCl concentrations and pre-stretching. Then, a coupled mechanochemical model, aimed at describing the smooth cell behavior and its influence on the passive and active mechanical response of the vascular tissue, is calibrated from the experimental measurements. Due to the complex stress and strain fields developed in the artery, a finite element numerical simulation of the test is performed to fit the model parameters, where those related to the phosphorylation and dephosphorylation activity along with the load-bearing capacity of the myosin cross-bridges are found to be the most predominant when sensitizing the active response. The main strengths of the model are associated with the prediction of the stationary state of the active mechanical response of the tissue through a realistic description of the mechanochemical process carried out at its cellular level.

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Section: Open Access Edited Bymentioning

confidence: 99%