Modeling the epidemiological situation with viral hepatitis C in the Russian Federation: opportunities and challenges

Uyshuk, N.D.; Ivakhnenko, O.; Znoyko, O. O.; Климова, Е А; Dudina, K.R.; Beliy, P.A.; Зайратьянц, О. В.; Omelyanovskiy, V. V.; Михайлов, М. И.; Kuregyan, K.K.; Malinnikova, E. Yu.

doi:10.20953/1729-9225-2019-1-105-114

Cited by 3 publications

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“…Хронические вирусные гепатиты В и С (ХГВ, ХВС) относятся к социально значимым инфекциям, получившим широкое распространение в настоящее время [1][2][3][4][5][6]. По данным ВОЗ за 2019 г., в мире с ХГВ проживали более 290 млн человек и более 58 млн были инфицированы вирусом гепатита С (ВГС).…”

Section: Original Studiesunclassified

Pregnancy and Childbirth Course Pecuarities in Women Suffering From Chronic Viral Hepatitis

Abdikerimova

2024

Hepatol Gastroenterol

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Background. Chronic viral hepatitis (CVH) B and C are considered socially significant infections. More than 290 million people worldwide live with chronic hepatitis B (CHB) and more than 58 million have been infected with hepatitis C virus (HCV). Every year, about 1.5 million people become newly infected. In recent years, chronic hepatitis has occupied one of the leading places in the structure of extragenital pathology in pregnant women. Objective. To evaluate the characteristics of pregnancy and childbirth course in women with CHB, CHC and CHB+СHC. Material and methods. The paper presents the results of a retrospective analysis of 141 individual records of pregnant women with CHB, CHC and CHB+СHC and their birth histories. The average age of pregnant women was 25.1±3.72 years. Results. CHB, CHC and CHB+СHC negatively affect the course of pregnancy: the threat of miscarriage and the frequency of gestosis increase, chronic fetoplacental insufficiency and polyhydramnios are more often detected, premature birth occurs as well. Childbirth in pregnant women with chronic hepatitis is accompanied by the development of complications: hypotonic uterine contractions, premature rupture of membranes. Chronic HCV-infection causes more serious metabolic changes than HBV, which significantly complicate the course of pregnancy and childbirth. Conclusions. CHB, CHC and CHB+СHC negatively affect the course of pregnancy and childbirth.

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Section: Original Studiesunclassified

Pregnancy and Childbirth Course Pecuarities in Women Suffering From Chronic Viral Hepatitis

Abdikerimova

2024

Hepatol Gastroenterol

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“…Хронический гепатит С (ХГС) представляет актуальную проблему в связи с широким его распространением, высоким риском развития цирроза печени и гепатоцеллюлярной карциномы [1][2][3][4][5]. В мире 3-5% населения инфицировано HCV (в том числе 0,3-0,7% детей), летальность достигает 350 тысяч случаев в год [6,7].…”

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The Signs of Carbohydrate-Lipid Metabolism Disturbance in Patients With Chronic Hepatitis C

Jeenalieva¹

2021

Hepatol and Gastroenterol

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Background. Viral hepatitis C (CHC) is an urgent problem due to its prevalence, high risk of developing liver cirrhosis and hepatocellular carcinoma. Viral hepatitis C can cause disruption of many biochemical processes in the liver cells, primarily that of carbohydrate - lipid metabolism. Objective. To study carbohydrate-lipid metabolism disturbances in patients with CHC. Material and methods. The study included 124 patients with paucisymptomatic chronic hepatitis C. The metabolic syndrome was diagnosed according to the indicators recommended by the Committee of Experts of the Russian Society of Cardiology (2007). Results. The parameters of lipid metabolism were studied in 52 of 124 patients with CHC. 29 of 52 patients with CHC (55.7%) showed a decrease in HDL cholesterol and an increase in LDL cholesterol, including a 2- fold increase in VLDL. The metabolic syndrome was detected in 22.5% of patients with CHC, 62.9% of patients had the manifestations of dyslipidemia (steatosis or steatohepatitis of the liver, obesity, arterial hypertension, insulin resistance, type 2 diabetes mellitus). Conclusions. In patients with CHC, carbohydrate-lipid metabolism disturbance was revealed as an integral indicator of metabolic syndrome, its incidence rising with the increase in activity and duration of the infectious process.

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Comparative evaluation of various strategies medical care for chronic hepatitis С in the Republic of Sakha (Yakutia)

Слепцова¹,

Sleptsov²,

Semenova³

2021

VIČ-infekc. immunosupr.

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Hepatitis C is a major public health problem and measures against it require the development of a national strategy and concept of a prognostic model. This is relevant for Yakutia, as a tremendous region with extremely specific and severe climatic and social conditions that cause a high incidence of hepatitis C.Objective: to evaluate the effectiveness of various scenarios for the development of the epidemiological situation of hepatitis C in RS (Y) depending on the strategy for providing medical care to people with chronic hepatitis C.Material and Methods. The work uses the materials of official statistics of the Federal State Institution of Rospotrebnadzor for RS (Y) and information from the register «Chronic viral hepatitis in RS (Y). To assess the burden of disease, the main scenarios were analyzed using the dynamic Excel model.Results and discussion. RS (Y) is a disadvantaged territory of the Russian Federation for parenteral viral hepatitis, including hepatitis C. According to the register «Chronic viral hepatitis in RS (Y)», 14643 people are registered, of which with chronic hepatitis C — 7395, which amounted to 50,5%. The proportion of HCV infection in the group of people with cirrhosis is 44.1%, with hepatocellular carcinoma 59,3%, and 76% in the total structure of the dead. Implementation of the WHO scenario for hepatitis C will reduce mortality by 65%, the number of people with hepatocellular carcinoma by 66%, decompensated cirrhosis by 66% and reduce the overall incidence by 34% by 2030.Conclusion. Achieving the WHO goals by 2030 seems realistic when creating a regional strategy to eliminate HCV in RS (Y), which includes increasing access to therapy with modern drugs with direct antiviral effects, an interdisciplinary approach to the diagnosis and management of patients with chronic hepatitis C, specialties about the problem of chronic hepatitis C and the possibility of curing it.

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Modeling the epidemiological situation with viral hepatitis C in the Russian Federation: opportunities and challenges

Cited by 3 publications

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Pregnancy and Childbirth Course Pecuarities in Women Suffering From Chronic Viral Hepatitis

Pregnancy and Childbirth Course Pecuarities in Women Suffering From Chronic Viral Hepatitis

The Signs of Carbohydrate-Lipid Metabolism Disturbance in Patients With Chronic Hepatitis C

Comparative evaluation of various strategies medical care for chronic hepatitis С in the Republic of Sakha (Yakutia)

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