Organised crime is one of the most serious problems of our time, causing damage to the environment, and economy and hindering the sustainable development of modern society. The study aims to analyse the regional, historical, socio-political and other factors that affect the quality and effectiveness of international cooperation in the fight against organised crime. The study is based on an analysis of several critical factors that determine effective international cooperation in the fight against organised crime. The methodological basis of the study consists of such methods as comparative and structural-functional analysis, and formal legal methods, which were used to study the current state of organised crime, international mechanisms for combating it and their regulatory framework. The analysis was based on the experience of international cooperation in such countries as the United States, Ukraine, Japan, Australia and Cameroon. The study identified trends in the correlation between the level of organised crime and the level of corruption, regional factors, and the level of civil society development. The findings of the study confirm the view that the international legal obligations assumed by national governments only slightly affect the level of involvement of national authorities in the fight against international organised crime. The study establishes that high-quality international cooperation most often occurs between democracies, but cases of such cooperation between authoritarian and democratic governments are not an exception. The results of the study provide important conclusions for further analysis of organised crime and the possibilities of international cooperation between state authorities and other actors of international relations involved in the fight against organised crime