2022
DOI: 10.1016/j.xphs.2021.10.001
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Modeling the Percutaneous Absorption of Solvent-deposited Solids Over a Wide Dose Range

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Cited by 8 publications
(3 citation statements)
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“…Limitations include low number of included trials on the basis of skin cancers, which could have been avoided by a search strategy targeting a population of individuals with a history of skin cancer; evaluation of AEs limited to three categories with quantitative reports, which may overestimate effect measures on AEs; and inclusion of trials conducted with topical nicotinamide, whose pharmacokinetics is still being studied in translational research. [13][14][15] Recent advances on cutaneous absorption of nicotinamide supported our decision to use eligibility criteria encompassing topical nicotinamide. Nevertheless, estimates for cutaneous and biochemical AEs were nonsignificant, as was the estimate for topical nicotinamide in skin cancer subgroup analyses.…”
Section: Discussionmentioning
confidence: 99%
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“…Limitations include low number of included trials on the basis of skin cancers, which could have been avoided by a search strategy targeting a population of individuals with a history of skin cancer; evaluation of AEs limited to three categories with quantitative reports, which may overestimate effect measures on AEs; and inclusion of trials conducted with topical nicotinamide, whose pharmacokinetics is still being studied in translational research. [13][14][15] Recent advances on cutaneous absorption of nicotinamide supported our decision to use eligibility criteria encompassing topical nicotinamide. Nevertheless, estimates for cutaneous and biochemical AEs were nonsignificant, as was the estimate for topical nicotinamide in skin cancer subgroup analyses.…”
Section: Discussionmentioning
confidence: 99%
“…Nicotinamide and its lipophilic analog methyl nicotinate were similarly absorbed in ex vivo human skin, and in vivo dermal delivery of nicotinamide was greater with a binary vehicle of propylene glycol and linolenic acid. [13][14][15] This systematic review and meta-analysis aimed to assess the effect of nicotinamide for skin cancer chemoprophylaxis in a large population of patients regardless of immunosuppression status.…”
Section: Introductionmentioning
confidence: 99%
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